Abstract
Objective: To perform a meta-analysis of randomized trials comparing partial fundoplication (PF) with total (Nissen) fundoplication (TF) for gastroesophageal reflux disease in terms of morbidity, efficacy, and long-term symptomatology.
Data Sources: A structured Medline search for published studies.
Study Selection: The available literature from 1975 until June 2007 was searched using the Medical Subject Headings of the National Library of Medicine term fundoplication and the free-text terms fundoplication, surgery, and reflux. Data were analyzed using Review Manager software (Cochrane Collaboration, Oxford, England).
Data Extraction: Eleven trials were identified comparing TF with PF in 991 patients.
Data Synthesis: Total fundoplication resulted in a significantly higher incidence of postoperative dysphagia (odds ratio [OR], 1.82-3.93; P
Conclusions: Partial fundoplication is a safe and effective alternative to TF, resulting in significantly fewer reoperations and a better functional outcome. The poor quality of the included trials warrants caution in the interpretation of the results of this meta-analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 273-278 |
| Number of pages | 6 |
| Journal | Archives of Surgery |
| Volume | 144 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2009 |
Keywords
- RANDOMIZED CLINICAL-TRIAL
- LAPAROSCOPIC NISSEN FUNDOPLICATION
- ANTERIOR PARTIAL FUNDOPLICATION
- DOUBLE-BLIND TRIAL
- ANTIREFLUX SURGERY
- FOLLOW-UP
- TOUPET FUNDOPLICATION
- ESOPHAGEAL MOTILITY
- SURGICAL-TREATMENT
- BARRETT-ESOPHAGUS