Topical 5-fluorouracil in the treatment of Darier's disease

A. C. Knulst; H. Baart De La Faille; W. A. Van Vloten

doi:10.1111/j.1365-2133.1995.tb02679.x

Topical 5-fluorouracil in the treatment of Darier's disease

A. C. Knulst^*, H. Baart De La Faille, W. A. Van Vloten

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

Two patients suffering from therapy-resistant Darier's disease were treated with topical 5-fluorouracil (5-FU). The drug was applied in a concentration of 1% in a cream base, once daily, in left-right comparison with either 7.5% salicylic acid in petrolatum or 0.05% vitamin A acid cream. Both patients were on long-term treatment with oral retinoids. After 1 week of treatment, a considerable improvement was already apparent on the 5-FU-treated side, in comparison with the salicylic acid- and vitamin A acid-treated sides. Subsequent treatment of all skin lesions with 5-FU for a further 2 weeks resulted in complete clearance of the lesions. Remission periods were of 2-6 months duration. There were no significant adverse effects of treatment. Haematological parameters remained unchanged during the therapy. Topical 5-FU is a safe and useful addition to currently available treatments for Darier's disease.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	British Journal of Dermatology
Volume	133
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2133.1995.tb02679.x
Publication status	Published - 21 Sept 1995

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title = "Topical 5-fluorouracil in the treatment of Darier's disease",

abstract = "Two patients suffering from therapy-resistant Darier's disease were treated with topical 5-fluorouracil (5-FU). The drug was applied in a concentration of 1% in a cream base, once daily, in left-right comparison with either 7.5% salicylic acid in petrolatum or 0.05% vitamin A acid cream. Both patients were on long-term treatment with oral retinoids. After 1 week of treatment, a considerable improvement was already apparent on the 5-FU-treated side, in comparison with the salicylic acid- and vitamin A acid-treated sides. Subsequent treatment of all skin lesions with 5-FU for a further 2 weeks resulted in complete clearance of the lesions. Remission periods were of 2-6 months duration. There were no significant adverse effects of treatment. Haematological parameters remained unchanged during the therapy. Topical 5-FU is a safe and useful addition to currently available treatments for Darier's disease.",

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AB - Two patients suffering from therapy-resistant Darier's disease were treated with topical 5-fluorouracil (5-FU). The drug was applied in a concentration of 1% in a cream base, once daily, in left-right comparison with either 7.5% salicylic acid in petrolatum or 0.05% vitamin A acid cream. Both patients were on long-term treatment with oral retinoids. After 1 week of treatment, a considerable improvement was already apparent on the 5-FU-treated side, in comparison with the salicylic acid- and vitamin A acid-treated sides. Subsequent treatment of all skin lesions with 5-FU for a further 2 weeks resulted in complete clearance of the lesions. Remission periods were of 2-6 months duration. There were no significant adverse effects of treatment. Haematological parameters remained unchanged during the therapy. Topical 5-FU is a safe and useful addition to currently available treatments for Darier's disease.

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Topical 5-fluorouracil in the treatment of Darier's disease

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