Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?

K. C.M. Santegoets; L. Van Bon; W. B. Van Den Berg; M. H. Wenink; T. R.D.J. Radstake

doi:10.1016/j.febslet.2011.04.028

Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?

K. C.M. Santegoets
, L. Van Bon
, W. B. Van Den Berg
, M. H. Wenink
, T. R.D.J. Radstake^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis TLR signaling is likely to be involved in tolerance breakthrough and chronic inflammation via combined Fc gamma receptors and TLR recognition of immune complexes. Furthermore, inflammatory diseases like psoriatic arthritis and gout also show more and more evidence for TLR involvement. In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings.

Original language	English
Pages (from-to)	3660-3666
Number of pages	7
Journal	FEBS letters
Volume	585
Issue number	23
DOIs	https://doi.org/10.1016/j.febslet.2011.04.028
Publication status	Published - 1 Dec 2011

Keywords

Autoimmunity
Innate immunity
Rheumatologic disease
Toll-like receptor

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10.1016/j.febslet.2011.04.028

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title = "Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?",

abstract = "In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis TLR signaling is likely to be involved in tolerance breakthrough and chronic inflammation via combined Fc gamma receptors and TLR recognition of immune complexes. Furthermore, inflammatory diseases like psoriatic arthritis and gout also show more and more evidence for TLR involvement. In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings.",

keywords = "Autoimmunity, Innate immunity, Rheumatologic disease, Toll-like receptor",

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T2 - Are we paying a high price for our defense against bugs?

AU - Santegoets, K. C.M.

AU - Van Bon, L.

AU - Van Den Berg, W. B.

AU - Wenink, M. H.

AU - Radstake, T. R.D.J.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis TLR signaling is likely to be involved in tolerance breakthrough and chronic inflammation via combined Fc gamma receptors and TLR recognition of immune complexes. Furthermore, inflammatory diseases like psoriatic arthritis and gout also show more and more evidence for TLR involvement. In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings.

AB - In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis TLR signaling is likely to be involved in tolerance breakthrough and chronic inflammation via combined Fc gamma receptors and TLR recognition of immune complexes. Furthermore, inflammatory diseases like psoriatic arthritis and gout also show more and more evidence for TLR involvement. In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings.

KW - Autoimmunity

KW - Innate immunity

KW - Rheumatologic disease

KW - Toll-like receptor

UR - https://www.scopus.com/pages/publications/81755161555

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M3 - Review article

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SN - 0014-5793

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EP - 3666

JO - FEBS letters

JF - FEBS letters

IS - 23

ER -

Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?

Abstract

Keywords

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