Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease

Maarten R. Hillen; Timothy R.D.J. Radstake; Cornelis E. Hack; Joel A.G. van Roon

doi:10.1093/rheumatology/kev241

Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease

Maarten R. Hillen, Timothy R.D.J. Radstake, Cornelis E. Hack, Joel A.G. van Roon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine that has been studied extensively in atopic diseases and more recently in various rheumatic disorders. It is involved in T cell development in the thymus and promotes homeostatic T cell expansion by classical dendritic cells. However, deregulated TSLP expression in various rheumatic diseases has implicated this cytokine as a strong mediator in immunopathology. Overexpressed TSLP induces strong T cell activation and production of pro-inflammatory cytokines in human cells and animal models for RA, SSc and LN, underscoring the therapeutic potential of targeting the TSLP-TSLP receptor axis.

Original language	English
Pages (from-to)	1771-1779
Number of pages	9
Journal	Rheumatology (Oxford, England)
Volume	54
Issue number	10
DOIs	https://doi.org/10.1093/rheumatology/kev241
Publication status	Published - Oct 2015

Keywords

Dendritic cells
Immunopathology
T cells
Thymic stromal lymphopoietin

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title = "Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease",

abstract = "Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine that has been studied extensively in atopic diseases and more recently in various rheumatic disorders. It is involved in T cell development in the thymus and promotes homeostatic T cell expansion by classical dendritic cells. However, deregulated TSLP expression in various rheumatic diseases has implicated this cytokine as a strong mediator in immunopathology. Overexpressed TSLP induces strong T cell activation and production of pro-inflammatory cytokines in human cells and animal models for RA, SSc and LN, underscoring the therapeutic potential of targeting the TSLP-TSLP receptor axis.",

keywords = "Dendritic cells, Immunopathology, T cells, Thymic stromal lymphopoietin",

author = "Hillen, {Maarten R.} and Radstake, {Timothy R.D.J.} and Hack, {Cornelis E.} and {van Roon}, {Joel A.G.}",

note = "Publisher Copyright: {\textcopyright} The Author 2015.",

year = "2015",

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doi = "10.1093/rheumatology/kev241",

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T1 - Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease

AU - Hillen, Maarten R.

AU - Radstake, Timothy R.D.J.

AU - Hack, Cornelis E.

AU - van Roon, Joel A.G.

N1 - Publisher Copyright: © The Author 2015.

PY - 2015/10

Y1 - 2015/10

N2 - Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine that has been studied extensively in atopic diseases and more recently in various rheumatic disorders. It is involved in T cell development in the thymus and promotes homeostatic T cell expansion by classical dendritic cells. However, deregulated TSLP expression in various rheumatic diseases has implicated this cytokine as a strong mediator in immunopathology. Overexpressed TSLP induces strong T cell activation and production of pro-inflammatory cytokines in human cells and animal models for RA, SSc and LN, underscoring the therapeutic potential of targeting the TSLP-TSLP receptor axis.

AB - Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine that has been studied extensively in atopic diseases and more recently in various rheumatic disorders. It is involved in T cell development in the thymus and promotes homeostatic T cell expansion by classical dendritic cells. However, deregulated TSLP expression in various rheumatic diseases has implicated this cytokine as a strong mediator in immunopathology. Overexpressed TSLP induces strong T cell activation and production of pro-inflammatory cytokines in human cells and animal models for RA, SSc and LN, underscoring the therapeutic potential of targeting the TSLP-TSLP receptor axis.

KW - Dendritic cells

KW - Immunopathology

KW - T cells

KW - Thymic stromal lymphopoietin

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DO - 10.1093/rheumatology/kev241

M3 - Article

C2 - 26163286

SN - 1462-0324

VL - 54

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EP - 1779

JO - Rheumatology (Oxford, England)

JF - Rheumatology (Oxford, England)

IS - 10

ER -

Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease

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