Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Robert Beun; Nuray Kusadasi; Maaike Sikma; Jan Westerink; Albert Huisman

doi:10.1111/ijlh.13230

Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Robert Beun
, Nuray Kusadasi
, Maaike Sikma
, Jan Westerink
, Albert Huisman

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

4 Downloads (Pure)

Abstract

In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.

Original language	English
Pages (from-to)	19-20
Number of pages	2
Journal	International Journal of Laboratory Hematology
Volume	42
Issue number	S1
Early online date	20 Apr 2020
DOIs	https://doi.org/10.1111/ijlh.13230
Publication status	Published - Jun 2020

Keywords

COVID19, SARS-CoV-2, corona, SARS, heparin
Intensive Care Units
Pandemics
Humans
Middle Aged
Pulmonary Embolism/complications
Drug Tolerance
Male
Anticoagulants/therapeutic use
Factor Xa/analysis
Betacoronavirus/isolation & purification
Drug Monitoring/methods
Factor VIII/analysis
Clinical Laboratory Techniques/methods
Fibrinogen/analysis
Pneumonia, Viral/complications
Biomarkers/blood
Female
Heparin/therapeutic use
Aged
Coronavirus Infections/complications
Fibrin Fibrinogen Degradation Products/analysis
Cohort Studies
Disseminated Intravascular Coagulation/complications

Access to Document

10.1111/ijlh.13230

ijlh.13230Final published version, 342 KB

Cite this

@article{4af3deab0bbf430f9cd17947486be070,

title = "Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2",

abstract = "In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71\% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6\% in patients who survived.",

keywords = "COVID19, SARS-CoV-2, corona, SARS, heparin, Intensive Care Units, Pandemics, Humans, Middle Aged, Pulmonary Embolism/complications, Drug Tolerance, Male, Anticoagulants/therapeutic use, Factor Xa/analysis, Betacoronavirus/isolation \& purification, Drug Monitoring/methods, Factor VIII/analysis, Clinical Laboratory Techniques/methods, Fibrinogen/analysis, Pneumonia, Viral/complications, Biomarkers/blood, Female, Heparin/therapeutic use, Aged, Coronavirus Infections/complications, Fibrin Fibrinogen Degradation Products/analysis, Cohort Studies, Disseminated Intravascular Coagulation/complications",

author = "Robert Beun and Nuray Kusadasi and Maaike Sikma and Jan Westerink and Albert Huisman",

year = "2020",

month = jun,

doi = "10.1111/ijlh.13230",

language = "English",

volume = "42",

pages = "19--20",

journal = "International Journal of Laboratory Hematology",

issn = "1751-5521",

publisher = "John Wiley \& Sons Inc.",

number = "S1",

}

TY - JOUR

T1 - Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

AU - Beun, Robert

AU - Kusadasi, Nuray

AU - Sikma, Maaike

AU - Westerink, Jan

AU - Huisman, Albert

PY - 2020/6

Y1 - 2020/6

N2 - In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.

AB - In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.

KW - COVID19, SARS-CoV-2, corona, SARS, heparin

KW - Intensive Care Units

KW - Pandemics

KW - Humans

KW - Middle Aged

KW - Pulmonary Embolism/complications

KW - Drug Tolerance

KW - Male

KW - Anticoagulants/therapeutic use

KW - Factor Xa/analysis

KW - Betacoronavirus/isolation & purification

KW - Drug Monitoring/methods

KW - Factor VIII/analysis

KW - Clinical Laboratory Techniques/methods

KW - Fibrinogen/analysis

KW - Pneumonia, Viral/complications

KW - Biomarkers/blood

KW - Female

KW - Heparin/therapeutic use

KW - Aged

KW - Coronavirus Infections/complications

KW - Fibrin Fibrinogen Degradation Products/analysis

KW - Cohort Studies

KW - Disseminated Intravascular Coagulation/complications

UR - https://www.scopus.com/pages/publications/85083956514

U2 - 10.1111/ijlh.13230

DO - 10.1111/ijlh.13230

M3 - Comment/Letter to the editor

C2 - 32311843

SN - 1751-5521

VL - 42

SP - 19

EP - 20

JO - International Journal of Laboratory Hematology

JF - International Journal of Laboratory Hematology

IS - S1

ER -

Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this