Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Robert Beun; Nuray Kusadasi; Maaike Sikma; Jan Westerink; Albert Huisman

doi:10.1111/ijlh.13230

Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Robert Beun, Nuray Kusadasi, Maaike Sikma, Jan Westerink, Albert Huisman

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.

Original language	English
Pages (from-to)	19-20
Number of pages	2
Journal	International Journal of Laboratory Hematology
Volume	42
Issue number	S1
Early online date	20 Apr 2020
DOIs	https://doi.org/10.1111/ijlh.13230
Publication status	Published - Jun 2020

Keywords

COVID19, SARS-CoV-2, corona, SARS, heparin
Intensive Care Units
Pandemics
Humans
Middle Aged
Pulmonary Embolism/complications
Drug Tolerance
Male
Anticoagulants/therapeutic use
Factor Xa/analysis
Betacoronavirus/isolation & purification
Drug Monitoring/methods
Factor VIII/analysis
Clinical Laboratory Techniques/methods
Fibrinogen/analysis
Pneumonia, Viral/complications
Biomarkers/blood
Female
Heparin/therapeutic use
Aged
Coronavirus Infections/complications
Fibrin Fibrinogen Degradation Products/analysis
Cohort Studies
Disseminated Intravascular Coagulation/complications

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10.1111/ijlh.13230

ijlh.13230Final published version, 342 KB

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title = "Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2",

abstract = "In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.",

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author = "Robert Beun and Nuray Kusadasi and Maaike Sikma and Jan Westerink and Albert Huisman",

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AU - Kusadasi, Nuray

AU - Sikma, Maaike

AU - Westerink, Jan

AU - Huisman, Albert

PY - 2020/6

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KW - Clinical Laboratory Techniques/methods

KW - Fibrinogen/analysis

KW - Pneumonia, Viral/complications

KW - Biomarkers/blood

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KW - Heparin/therapeutic use

KW - Aged

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KW - Fibrin Fibrinogen Degradation Products/analysis

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M3 - Comment/Letter to the editor

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JO - International Journal of Laboratory Hematology

JF - International Journal of Laboratory Hematology

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ER -

Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

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Keywords

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