Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Robert Beun, Nuray Kusadasi, Maaike Sikma, Jan Westerink, Albert Huisman

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.

Original languageEnglish
Pages (from-to)19-20
Number of pages2
JournalInternational Journal of Laboratory Hematology
Issue numberS1
Early online date20 Apr 2020
Publication statusPublished - Jun 2020


  • COVID19, SARS-CoV-2, corona, SARS, heparin
  • Intensive Care Units
  • Pandemics
  • Humans
  • Middle Aged
  • Pulmonary Embolism/complications
  • Drug Tolerance
  • Male
  • Anticoagulants/therapeutic use
  • Factor Xa/analysis
  • Betacoronavirus/isolation & purification
  • Drug Monitoring/methods
  • Factor VIII/analysis
  • Clinical Laboratory Techniques/methods
  • Fibrinogen/analysis
  • Pneumonia, Viral/complications
  • Biomarkers/blood
  • Female
  • Heparin/therapeutic use
  • Aged
  • Coronavirus Infections/complications
  • Fibrin Fibrinogen Degradation Products/analysis
  • Cohort Studies
  • Disseminated Intravascular Coagulation/complications


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