Therapeutic strategies to rescue damaged heart

Juntao Fang

doi:10.33540/1893

Therapeutic strategies to rescue damaged heart

Juntao Fang

Department of Experimental Cardiology

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

Heart failure is a complex and common condition with a poor prognosis and increasing incidence. Unfortunately, end-stage heart failure can only be treated with heart replacement therapy or mechanical support devices, which also have some limitations. The studies described in this dissertation aim to impede the progression of heart failure caused by ischemia/pressure overload by using various strategies such as gene therapy, direct reprogramming from fibroblasts into cardiomyocytes, mechanical unloading induced reverse cardiac remodeling, and the regulation of polyploidy state of cardiomyocytes.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Sluijter, Joost, Primary supervisor Schiffelers, Raymond, Supervisor Lei, Zhiyong, Co-supervisor
Award date	18 Sept 2023
Place of Publication	Utrecht
Publisher	Utrecht University
Print ISBNs	978-94-6469-528-1
DOIs	https://doi.org/10.33540/1893
Publication status	Published - 18 Sept 2023

Keywords

Heart failure
miR-132/212
Direct cardiac reprogramming
Vitamin C
Senescence
RB1
Mechanical unloading
CITED4
Cardiomyocytes polyploidy
E2F7/8

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10.33540/1893

https://dspace.library.uu.nl/handle/1874/430724

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Cite this

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KW - Direct cardiac reprogramming

KW - Vitamin C

KW - Senescence

KW - RB1

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ER -

Therapeutic strategies to rescue damaged heart

Abstract

Keywords

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