The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

M.P.J.K. Lolkema; D.A. Mans; C.M.J.T. Snijckers; M. van Noort; M. van Beest; E.E. Voest; R.H. Giles

doi:10.1016/j.febslet.2007.08.050

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

M.P.J.K. Lolkema, D.A. Mans, C.M.J.T. Snijckers, M. van Noort, M. van Beest, E.E. Voest, R.H. Giles

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.

Original language	English
Pages (from-to)	4571-4576
Number of pages	6
Journal	FEBS letters
Volume	581
Issue number	24
DOIs	https://doi.org/10.1016/j.febslet.2007.08.050
Publication status	Published - 2007

Keywords

Alleles
Animals
Cell Line
Humans
Kinesin
Mice
Microtubules
Mutation
Protein Binding
Von Hippel-Lindau Tumor Suppressor Protein

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10.1016/j.febslet.2007.08.050

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title = "The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2",

abstract = "Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.",

keywords = "Alleles, Animals, Cell Line, Humans, Kinesin, Mice, Microtubules, Mutation, Protein Binding, Von Hippel-Lindau Tumor Suppressor Protein",

author = "M.P.J.K. Lolkema and D.A. Mans and C.M.J.T. Snijckers and {van Noort}, M. and {van Beest}, M. and E.E. Voest and R.H. Giles",

year = "2007",

doi = "10.1016/j.febslet.2007.08.050",

language = "English",

volume = "581",

pages = "4571--4576",

journal = "FEBS letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "24",

}

TY - JOUR

T1 - The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

AU - Lolkema, M.P.J.K.

AU - Mans, D.A.

AU - Snijckers, C.M.J.T.

AU - van Noort, M.

AU - van Beest, M.

AU - Voest, E.E.

AU - Giles, R.H.

PY - 2007

Y1 - 2007

N2 - Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.

AB - Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.

KW - Alleles

KW - Animals

KW - Cell Line

KW - Humans

KW - Kinesin

KW - Mice

KW - Microtubules

KW - Mutation

KW - Protein Binding

KW - Von Hippel-Lindau Tumor Suppressor Protein

U2 - 10.1016/j.febslet.2007.08.050

DO - 10.1016/j.febslet.2007.08.050

M3 - Article

C2 - 17825299

SN - 0014-5793

VL - 581

SP - 4571

EP - 4576

JO - FEBS letters

JF - FEBS letters

IS - 24

ER -

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

Abstract

Keywords

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