The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci

Translated title of the contribution: The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci

C.J. Arnusch, A.M.J.J. Bonvin, A.M. Verel, W.T.M. Jansen, R.M.J. Liskamp, B. de Kruijff, R.J. Pieters, E.J. Breukink

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Lipid II is a crucial component in bacterial cell wall synthesis [Breukink, E., et al. (1999) Science 286, 2361−2364]. It is the target of a number of important antibiotics, which include vancomycin and nisin [Breukink, E., and de Kruijff, B. (2006) Nat. Rev. Drug Discovery 5, 321−332]. Here we show that a hybrid antibiotic that consists of vancomycin and nisin fragments is significantly more active than the separate fragments against vancomycin resistant entercocci (VRE). Three different hybrids were synthesized using click chemistry and compared. Optimal spacer lengths and connection points were predicted using computer modeling.
Translated title of the contributionThe vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci
Original languageUndefined/Unknown
Pages (from-to)12661-12663
Number of pages3
JournalBiochemistry
Volume47
Issue number48
Publication statusPublished - 2008

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