The value of yttrium-90 PET/CT after hepatic radioembolization: a pictorial essay

Ahmed A. Alsultan; Maarten L.J. Smits; Maarten W. Barentsz; Arthur J.A.T. Braat; Marnix G.E.H. Lam

doi:10.1007/s40336-019-00335-2

The value of yttrium-90 PET/CT after hepatic radioembolization: a pictorial essay

Ahmed A. Alsultan^*
, Maarten L.J. Smits
, Maarten W. Barentsz
, Arthur J.A.T. Braat
, Marnix G.E.H. Lam

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Introduction: Distribution of microspheres after radioembolization can be accurately visualized using PET/CT. In this pictorial essay, we aim to demonstrate the value of ⁹⁰Y-PET/CT after radioembolization. Methods: ⁹⁰Y-PET/CT imaging was routinely performed after radioembolization at our institute. Patients were scanned the same day or the day after treatment, using a scanner with time-of-flight technology. We retrospectively reviewed all ⁹⁰Y-PET/CTs from patients treated with radioembolization (both glass and resin microspheres) between January 2011 and January 2019. Five cases were selected that are illustrative of the added value of PET/CT after radioembolization. Results: ⁹⁰Y-PET/CT allows for distribution assessment and dosimetry of ⁹⁰Y-microspheres. It was used for the assessment of treatment success by visualization of tumor targeting, quantification of the absorbed dose, prediction of complications such as radioembolization-induced liver disease, and determining the required dosage for retreatment. Conclusion: PET/CT is an excellent modality for post-treatment imaging of ⁹⁰Y-microspheres and could lead to improved dose planning and more personalized treatment.

Original language	English
Pages (from-to)	303-312
Number of pages	10
Journal	Clinical and translational imaging
Volume	7
Issue number	4
DOIs	https://doi.org/10.1007/s40336-019-00335-2
Publication status	Published - 1 Aug 2019

Keywords

Y-microspheres
Y-PET/CT
Intra-arterial radioembolization
Post-treatment imaging
CT
Y-90-PET
Y-90-microspheres

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title = "The value of yttrium-90 PET/CT after hepatic radioembolization: a pictorial essay",

abstract = "Introduction: Distribution of microspheres after radioembolization can be accurately visualized using PET/CT. In this pictorial essay, we aim to demonstrate the value of 90Y-PET/CT after radioembolization. Methods: 90Y-PET/CT imaging was routinely performed after radioembolization at our institute. Patients were scanned the same day or the day after treatment, using a scanner with time-of-flight technology. We retrospectively reviewed all 90Y-PET/CTs from patients treated with radioembolization (both glass and resin microspheres) between January 2011 and January 2019. Five cases were selected that are illustrative of the added value of PET/CT after radioembolization. Results: 90Y-PET/CT allows for distribution assessment and dosimetry of 90Y-microspheres. It was used for the assessment of treatment success by visualization of tumor targeting, quantification of the absorbed dose, prediction of complications such as radioembolization-induced liver disease, and determining the required dosage for retreatment. Conclusion: PET/CT is an excellent modality for post-treatment imaging of 90Y-microspheres and could lead to improved dose planning and more personalized treatment.",

keywords = "Y-microspheres, Y-PET/CT, Intra-arterial radioembolization, Post-treatment imaging, CT, Y-90-PET, Y-90-microspheres",

author = "Alsultan, \{Ahmed A.\} and Smits, \{Maarten L.J.\} and Barentsz, \{Maarten W.\} and Braat, \{Arthur J.A.T.\} and Lam, \{Marnix G.E.H.\}",

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doi = "10.1007/s40336-019-00335-2",

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T2 - a pictorial essay

AU - Alsultan, Ahmed A.

AU - Smits, Maarten L.J.

AU - Barentsz, Maarten W.

AU - Braat, Arthur J.A.T.

AU - Lam, Marnix G.E.H.

PY - 2019/8/1

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N2 - Introduction: Distribution of microspheres after radioembolization can be accurately visualized using PET/CT. In this pictorial essay, we aim to demonstrate the value of 90Y-PET/CT after radioembolization. Methods: 90Y-PET/CT imaging was routinely performed after radioembolization at our institute. Patients were scanned the same day or the day after treatment, using a scanner with time-of-flight technology. We retrospectively reviewed all 90Y-PET/CTs from patients treated with radioembolization (both glass and resin microspheres) between January 2011 and January 2019. Five cases were selected that are illustrative of the added value of PET/CT after radioembolization. Results: 90Y-PET/CT allows for distribution assessment and dosimetry of 90Y-microspheres. It was used for the assessment of treatment success by visualization of tumor targeting, quantification of the absorbed dose, prediction of complications such as radioembolization-induced liver disease, and determining the required dosage for retreatment. Conclusion: PET/CT is an excellent modality for post-treatment imaging of 90Y-microspheres and could lead to improved dose planning and more personalized treatment.

AB - Introduction: Distribution of microspheres after radioembolization can be accurately visualized using PET/CT. In this pictorial essay, we aim to demonstrate the value of 90Y-PET/CT after radioembolization. Methods: 90Y-PET/CT imaging was routinely performed after radioembolization at our institute. Patients were scanned the same day or the day after treatment, using a scanner with time-of-flight technology. We retrospectively reviewed all 90Y-PET/CTs from patients treated with radioembolization (both glass and resin microspheres) between January 2011 and January 2019. Five cases were selected that are illustrative of the added value of PET/CT after radioembolization. Results: 90Y-PET/CT allows for distribution assessment and dosimetry of 90Y-microspheres. It was used for the assessment of treatment success by visualization of tumor targeting, quantification of the absorbed dose, prediction of complications such as radioembolization-induced liver disease, and determining the required dosage for retreatment. Conclusion: PET/CT is an excellent modality for post-treatment imaging of 90Y-microspheres and could lead to improved dose planning and more personalized treatment.

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KW - Intra-arterial radioembolization

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KW - Y-90-microspheres

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ER -

The value of yttrium-90 PET/CT after hepatic radioembolization: a pictorial essay

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