The value of yttrium-90 PET/CT after hepatic radioembolization: a pictorial essay

Ahmed A. Alsultan*, Maarten L.J. Smits, Maarten W. Barentsz, Arthur J.A.T. Braat, Marnix G.E.H. Lam

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: Distribution of microspheres after radioembolization can be accurately visualized using PET/CT. In this pictorial essay, we aim to demonstrate the value of 90Y-PET/CT after radioembolization. Methods: 90Y-PET/CT imaging was routinely performed after radioembolization at our institute. Patients were scanned the same day or the day after treatment, using a scanner with time-of-flight technology. We retrospectively reviewed all 90Y-PET/CTs from patients treated with radioembolization (both glass and resin microspheres) between January 2011 and January 2019. Five cases were selected that are illustrative of the added value of PET/CT after radioembolization. Results: 90Y-PET/CT allows for distribution assessment and dosimetry of 90Y-microspheres. It was used for the assessment of treatment success by visualization of tumor targeting, quantification of the absorbed dose, prediction of complications such as radioembolization-induced liver disease, and determining the required dosage for retreatment. Conclusion: PET/CT is an excellent modality for post-treatment imaging of 90Y-microspheres and could lead to improved dose planning and more personalized treatment.

Original languageEnglish
Pages (from-to)303-312
Number of pages10
JournalClinical and translational imaging
Issue number4
Publication statusPublished - 1 Aug 2019


  • Y-microspheres
  • Y-PET/CT
  • Intra-arterial radioembolization
  • Post-treatment imaging
  • CT
  • Y-90-PET
  • Y-90-microspheres


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