TY - JOUR
T1 - The 'Treg paradox' in inflammatory arthritis.
AU - Schnell, Julia T
AU - Briviesca, Raquel Laza
AU - Kim, Taehyeung
AU - Charbonnier, Louis-Marie
AU - Henderson, Lauren A
AU - van Wijk, Femke
AU - Nigrovic, Peter A
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2025/1
Y1 - 2025/1
N2 - Classic regulatory T (T
reg) cells expressing CD4 and the hallmark transcription factor FOXP3 are integral to the prevention of multi-system autoimmunity. However, immune-mediated arthritis is often associated with increased numbers of T
reg cells in the inflamed joints. To understand these seemingly conflicting observations, which we collectively describe as 'the T
reg paradox', we provide an overview of T
reg cell biology with a focus on T
reg cell heterogeneity, function and dysfunction in arthritis. We discuss how the inflamed environment constrains the immunosuppressive activity of T
reg cells while also promoting the differentiation of T
H17-like T
reg cell, exT
reg cell (effector T cells that were formerly T
reg cells), and osteoclastogenic T
reg cell subsets that mediate tissue injury. We present a new framework to understand T
reg cells in joint inflammation and define potential strategies for T
reg cell-directed interventions in human inflammatory arthritis.
AB - Classic regulatory T (T
reg) cells expressing CD4 and the hallmark transcription factor FOXP3 are integral to the prevention of multi-system autoimmunity. However, immune-mediated arthritis is often associated with increased numbers of T
reg cells in the inflamed joints. To understand these seemingly conflicting observations, which we collectively describe as 'the T
reg paradox', we provide an overview of T
reg cell biology with a focus on T
reg cell heterogeneity, function and dysfunction in arthritis. We discuss how the inflamed environment constrains the immunosuppressive activity of T
reg cells while also promoting the differentiation of T
H17-like T
reg cell, exT
reg cell (effector T cells that were formerly T
reg cells), and osteoclastogenic T
reg cell subsets that mediate tissue injury. We present a new framework to understand T
reg cells in joint inflammation and define potential strategies for T
reg cell-directed interventions in human inflammatory arthritis.
UR - http://www.scopus.com/inward/record.url?scp=85211908858&partnerID=8YFLogxK
U2 - 10.1038/s41584-024-01190-w
DO - 10.1038/s41584-024-01190-w
M3 - Review article
C2 - 39653758
SN - 1759-4790
VL - 21
SP - 9
EP - 21
JO - Nature Reviews. Rheumatology
JF - Nature Reviews. Rheumatology
IS - 1
M1 - e141008
ER -