The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

Apfrida Kendek; Marieke R. Wensveen; Aniek Janssen

doi:10.3390/genes12091415

The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

Apfrida Kendek, Marieke R. Wensveen, Aniek Janssen

Research output: Contribution to journal › Review article › peer-review

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Abstract

The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage. Silenced chromatin domains in particular present a major challenge to the cell’s DNA repair machinery due to their specific biophysical properties and distinct, often repetitive, DNA content. To this end, we here discuss the interplay between silenced chromatin domains and DNA damage repair, specifically double-strand breaks, and how these processes help maintain genome stability.

Original language	English
Article number	1415
Journal	Genes
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/genes12091415
Publication status	Published - Sept 2021

Keywords

DNA-damage repair
constitutive heterochromatin
double-strand breaks
facultative heterochromatin

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10.3390/genes12091415Licence: CC BY

genes-12-01415-v2Final published version, 1.25 MBLicence: CC BY

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title = "The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks",

abstract = "The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage. Silenced chromatin domains in particular present a major challenge to the cell{\textquoteright}s DNA repair machinery due to their specific biophysical properties and distinct, often repetitive, DNA content. To this end, we here discuss the interplay between silenced chromatin domains and DNA damage repair, specifically double-strand breaks, and how these processes help maintain genome stability.",

keywords = "DNA-damage repair, constitutive heterochromatin, double-strand breaks, facultative heterochromatin",

author = "Apfrida Kendek and Wensveen, {Marieke R.} and Aniek Janssen",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

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doi = "10.3390/genes12091415",

language = "English",

volume = "12",

journal = "Genes",

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T1 - The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

AU - Kendek, Apfrida

AU - Wensveen, Marieke R.

AU - Janssen, Aniek

PY - 2021/9

Y1 - 2021/9

N2 - The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage. Silenced chromatin domains in particular present a major challenge to the cell’s DNA repair machinery due to their specific biophysical properties and distinct, often repetitive, DNA content. To this end, we here discuss the interplay between silenced chromatin domains and DNA damage repair, specifically double-strand breaks, and how these processes help maintain genome stability.

AB - The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage. Silenced chromatin domains in particular present a major challenge to the cell’s DNA repair machinery due to their specific biophysical properties and distinct, often repetitive, DNA content. To this end, we here discuss the interplay between silenced chromatin domains and DNA damage repair, specifically double-strand breaks, and how these processes help maintain genome stability.

KW - DNA-damage repair

KW - constitutive heterochromatin

KW - double-strand breaks

KW - facultative heterochromatin

U2 - 10.3390/genes12091415

DO - 10.3390/genes12091415

M3 - Review article

SN - 2073-4425

VL - 12

JO - Genes

JF - Genes

IS - 9

M1 - 1415

ER -

The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

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