The severity of chronic histiocytic intervillositis is associated with gestational age and fetal weight

M. Bos, M. J.M. Koenders, K. L. Dijkstra, L. E. van der Meeren, P. G.J. Nikkels, K. W.M. Bloemenkamp, M. Eikmans, H. J. Baelde, M. L.P. van der Hoorn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Introduction: Chronic histiocytic intervillositis (CHI) is a rare histopathological lesion in the placenta that is associated with poor reproductive outcomes. The intervillous infiltrate consists mostly of maternal mononuclear cells and fibrin depositions, which are both indicators for the severity of the intervillous infiltrate. The severity of the intervillous infiltrate as well as the clinical outcomes of pregnancy differ between cases. Our objective is to determine the relation between the severity of the intervillous infiltrate and the clinical outcomes of CHI. Methods: Cases of CHI were semi-quantitatively graded based on histopathological severity scores. Hereto, CD68 positive mononuclear cells were quantified, fibrin depositions visualized by both a PTAH stain and an immuohistochemical staining, and placental dysfunction was assessed via thrombomodulin staining. Results: This study included 36 women with CHI. A higher CD68 score was significantly associated with a lower birthweight. Loss of placental thrombomodulin was associated with lower gestational age, lower birthweight, and a lower placenta weight. The combined severity score based on CD68 and PTAH was significantly associated with fetal growth restriction, and the joint score of CD68 and fibrin was associated with birthweight and placental weight. Discussion: More severe intervillous infiltrates in CHI placentas is associated with a lower birth weight and placental weight. Furthermore, this study proposes thrombomodulin as a possible new severity marker of placental damage. More research is needed to better understand the pathophysiology of CHI.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
Publication statusPublished - Jan 2023


  • Chronic histiocytic intervillositis
  • Chronic intervillositis of unknown etiology
  • Fetal growth restriction
  • Preterm birth
  • Thrombomodulin


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