TY - JOUR
T1 - The serotonin transporter 5-HTTLPR polymorphism in the association between sleep quality and affect
AU - Hartmann, Jessica A.
AU - Wichers, Marieke
AU - van Bemmel, Alex L.
AU - Derom, Catherine
AU - Thiery, Evert
AU - Jacobs, Nele
AU - van Os, Jim
AU - Simons, Claudia J P
PY - 2014/1/1
Y1 - 2014/1/1
N2 - A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (χ2=4.16, p= .042 and χ2=3.90, p= .048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication.
AB - A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (χ2=4.16, p= .042 and χ2=3.90, p= .048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication.
KW - 5-HTTLPR
KW - Daily life
KW - Experience sampling method
KW - Negative affect
KW - Positive affect
KW - Subjective sleep quality
UR - http://www.scopus.com/inward/record.url?scp=84902342234&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2014.01.015
DO - 10.1016/j.euroneuro.2014.01.015
M3 - Article
C2 - 24486182
AN - SCOPUS:84902342234
SN - 0924-977X
VL - 24
SP - 1086
EP - 1090
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 7
ER -