TY - JOUR
T1 - The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review
AU - Xu, Yong-Yue
AU - Wang, Dong-Mei
AU - Liang, Hua-Sheng
AU - Liu, Ze-Hao
AU - Li, Jun-Xia
AU - Wang, Mao-Jie
AU - Chen, Xiu-Min
AU - Balak, Deepak M. W.
AU - Radstake, Timothy R. D. J.
AU - Huang, Run-Yue
AU - Lu, Chuan-Jian
N1 - Funding Information:
This work was supported by the Optimization of psoriasis external application based on “receptor fishing technology” and its preclinical study (2018KT1233), the Hospital Chinese medicine preparation development project: Yinxieling tablets (Guangdong funding association 2015 No. 77), the Guangdong Province Science and Technology Department and Guangdong Provincial Academy of Chinese Medicine (Nos. 2014A020221031 and 2016A020226041), Science and Technology Planning Project of Guangdong Province (No. 2017B030314166), and the Guangzhou Municipal Science and Technology Innovation Committee (No. 201710010076). The study was also supported by the training project for excellent young teachers in colleges and universities in Guangdong (YQ2015044).
Publisher Copyright:
© 2020 World Scientific Publishing Company.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. In addition, the frequency analysis and network pharmacology for the collected TCM herbs from clinical trial data were performed. The studies reported the changes in the ratio of Th17 and/or Treg cells as well as their transcription factor and related cytokines were included. Frequency analysis of composition of the 39 assessed TCM prescriptions showed that Astragalus membranaceus var.mongholicus (5.20%), Glycyrrhiza uralensis (3.67%), Paeonia obovate (3.06%), Salvia digitaloides (3.06%), and Angelica sinensis (2.75%) were the top five herbal components, which were closely associated to the treatment of IMID. Network pharmacology showed that six target proteins (transforming growth factor (TGF)-beta receptor type-1, TGF-beta receptor type-2, retineic-acid-receptor-related orphan nuclear receptor gamma (ROR-gamma), TGFB2, IL-17 and IL-2, respectively) might be involved in the regulatory effects of TCM on Th17/Treg axis. Moreover, there were nine active ingredients (including Oxymatrine, Baicalin, Triptolide, Paeoniflorin, Sinomenine, Celastrol, Emodin, Diosgenin and Chlorogenic acid) originating from TCM reported to have an immunological regulation effect on the Th17/Treg axis. The highlight of this systematic review is to reveal the pharmacological basis of TCM treating IMID and is helpful for supporting future pharmacologic-driven studies. Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.
AB - The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. In addition, the frequency analysis and network pharmacology for the collected TCM herbs from clinical trial data were performed. The studies reported the changes in the ratio of Th17 and/or Treg cells as well as their transcription factor and related cytokines were included. Frequency analysis of composition of the 39 assessed TCM prescriptions showed that Astragalus membranaceus var.mongholicus (5.20%), Glycyrrhiza uralensis (3.67%), Paeonia obovate (3.06%), Salvia digitaloides (3.06%), and Angelica sinensis (2.75%) were the top five herbal components, which were closely associated to the treatment of IMID. Network pharmacology showed that six target proteins (transforming growth factor (TGF)-beta receptor type-1, TGF-beta receptor type-2, retineic-acid-receptor-related orphan nuclear receptor gamma (ROR-gamma), TGFB2, IL-17 and IL-2, respectively) might be involved in the regulatory effects of TCM on Th17/Treg axis. Moreover, there were nine active ingredients (including Oxymatrine, Baicalin, Triptolide, Paeoniflorin, Sinomenine, Celastrol, Emodin, Diosgenin and Chlorogenic acid) originating from TCM reported to have an immunological regulation effect on the Th17/Treg axis. The highlight of this systematic review is to reveal the pharmacological basis of TCM treating IMID and is helpful for supporting future pharmacologic-driven studies. Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.
KW - Immune-Mediated Inflammatory Diseases
KW - Systematic Review
KW - Th17/Treg Cells
KW - Traditional Chinese Medicine
UR - http://www.scopus.com/inward/record.url?scp=85084573669&partnerID=8YFLogxK
U2 - 10.1142/S0192415X20500275
DO - 10.1142/S0192415X20500275
M3 - Review article
SN - 0192-415X
VL - 48
SP - 535
EP - 558
JO - The American Journal of Chinese Medicine
JF - The American Journal of Chinese Medicine
IS - 3
ER -