The role of T cells in the development of cardiovascular disease in HIV-infected patients

M. Krikke; S. F. L. van Lelyveld; K. Tesselaar; J. E. Arends; I. M. Hoepelman; F. L. J. Visseren

doi:10.1016/j.atherosclerosis.2014.08.054

The role of T cells in the development of cardiovascular disease in HIV-infected patients

M. Krikke, S. F. L. van Lelyveld, K. Tesselaar, J. E. Arends^*, I. M. Hoepelman, F. L. J. Visseren

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

Cardiovascular disease (CVD) is highly prevalent in HIV-infected patients. Besides the classical cardiovascular risk factors, HIV related factors play a role, such as immune activation and treatment with highly active antiretroviral therapy (HAART). The resulting T cell activation is regarded as one of the driving forces behind this accelerated atherogenesis. Interventions, such as early treatment and anti-inflammatory therapy, decreasing T cell activation might lead to a lower incidence of CVD in future HIV infected patients. This review specifically explores the role of T cells in the development of atherosclerosis in HIV-infected patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	92-98
Number of pages	7
Journal	Atherosclerosis
Volume	237
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2014.08.054
Publication status	Published - Nov 2014

Keywords

HIV
HIV-infection
Cardiovascular disease
Immune activation
T cell activation
CD4+T cells
CD8+T cells
Monocytes
Monocyte activation
Atherosclerosis
Inflammatory markers
Coagulation markers
Endothelial markers
ACTIVE ANTIRETROVIRAL THERAPY
INTIMA-MEDIA THICKNESS
CORONARY-HEART-DISEASE
CAROTID-ARTERY-DISEASE
C-REACTIVE PROTEIN
IMMUNE ACTIVATION
MYOCARDIAL-INFARCTION
DEFICIENT MICE
RISK-FACTORS
ALL-CAUSE

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10.1016/j.atherosclerosis.2014.08.054

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title = "The role of T cells in the development of cardiovascular disease in HIV-infected patients",

abstract = "Cardiovascular disease (CVD) is highly prevalent in HIV-infected patients. Besides the classical cardiovascular risk factors, HIV related factors play a role, such as immune activation and treatment with highly active antiretroviral therapy (HAART). The resulting T cell activation is regarded as one of the driving forces behind this accelerated atherogenesis. Interventions, such as early treatment and anti-inflammatory therapy, decreasing T cell activation might lead to a lower incidence of CVD in future HIV infected patients. This review specifically explores the role of T cells in the development of atherosclerosis in HIV-infected patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.",

keywords = "HIV, HIV-infection, Cardiovascular disease, Immune activation, T cell activation, CD4+T cells, CD8+T cells, Monocytes, Monocyte activation, Atherosclerosis, Inflammatory markers, Coagulation markers, Endothelial markers, ACTIVE ANTIRETROVIRAL THERAPY, INTIMA-MEDIA THICKNESS, CORONARY-HEART-DISEASE, CAROTID-ARTERY-DISEASE, C-REACTIVE PROTEIN, IMMUNE ACTIVATION, MYOCARDIAL-INFARCTION, DEFICIENT MICE, RISK-FACTORS, ALL-CAUSE",

author = "M. Krikke and {van Lelyveld}, {S. F. L.} and K. Tesselaar and Arends, {J. E.} and Hoepelman, {I. M.} and Visseren, {F. L. J.}",

year = "2014",

month = nov,

doi = "10.1016/j.atherosclerosis.2014.08.054",

language = "English",

volume = "237",

pages = "92--98",

journal = "Atherosclerosis",

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publisher = "Elsevier",

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T1 - The role of T cells in the development of cardiovascular disease in HIV-infected patients

AU - Krikke, M.

AU - van Lelyveld, S. F. L.

AU - Tesselaar, K.

AU - Arends, J. E.

AU - Hoepelman, I. M.

AU - Visseren, F. L. J.

PY - 2014/11

Y1 - 2014/11

N2 - Cardiovascular disease (CVD) is highly prevalent in HIV-infected patients. Besides the classical cardiovascular risk factors, HIV related factors play a role, such as immune activation and treatment with highly active antiretroviral therapy (HAART). The resulting T cell activation is regarded as one of the driving forces behind this accelerated atherogenesis. Interventions, such as early treatment and anti-inflammatory therapy, decreasing T cell activation might lead to a lower incidence of CVD in future HIV infected patients. This review specifically explores the role of T cells in the development of atherosclerosis in HIV-infected patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

AB - Cardiovascular disease (CVD) is highly prevalent in HIV-infected patients. Besides the classical cardiovascular risk factors, HIV related factors play a role, such as immune activation and treatment with highly active antiretroviral therapy (HAART). The resulting T cell activation is regarded as one of the driving forces behind this accelerated atherogenesis. Interventions, such as early treatment and anti-inflammatory therapy, decreasing T cell activation might lead to a lower incidence of CVD in future HIV infected patients. This review specifically explores the role of T cells in the development of atherosclerosis in HIV-infected patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

KW - HIV

KW - HIV-infection

KW - Cardiovascular disease

KW - Immune activation

KW - T cell activation

KW - CD4+T cells

KW - CD8+T cells

KW - Monocytes

KW - Monocyte activation

KW - Atherosclerosis

KW - Inflammatory markers

KW - Coagulation markers

KW - Endothelial markers

KW - ACTIVE ANTIRETROVIRAL THERAPY

KW - INTIMA-MEDIA THICKNESS

KW - CORONARY-HEART-DISEASE

KW - CAROTID-ARTERY-DISEASE

KW - C-REACTIVE PROTEIN

KW - IMMUNE ACTIVATION

KW - MYOCARDIAL-INFARCTION

KW - DEFICIENT MICE

KW - RISK-FACTORS

KW - ALL-CAUSE

U2 - 10.1016/j.atherosclerosis.2014.08.054

DO - 10.1016/j.atherosclerosis.2014.08.054

M3 - Literature review

C2 - 25238214

SN - 0021-9150

VL - 237

SP - 92

EP - 98

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

The role of T cells in the development of cardiovascular disease in HIV-infected patients

Abstract

Keywords

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