The role of phosphatidylinositol 4-kinases in vesicular transport

P De Graaf; AJ Verkleij; PMP van Bergen en Henegouwen

The role of phosphatidylinositol 4-kinases in vesicular transport

P De Graaf^*, AJ Verkleij, PMP van Bergen en Henegouwen

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Phosphoinositide metabolism is involved in signal transduction, cytoskeletal organization and in vesicular transport. The main precursor for the different phosphoinositides, phosphatidylinositol(4)phosphate (PtdIns(4)P), is synthesized by phosphatidylinositol 4-kinase (PtdIns 4-kinase). Based on biochemical characterization the family of PtdIns 4-kinases has been divided in two types (II and III). Recently, two type III isoforms of this enzyme have been cloned and sequenced. Localization studies have shown a different location for these isoforms implying different functions for the PtdIns 4-kinases in vivo. In this chapter, we review the current data about PtdIns 4-kinases, and discuss the possible physiological function of PtdIns 4-kinase activity in vesicular transport.

Original language	English
Title of host publication	PROTEIN MODULES IN CELLULAR SIGNALLING
Editors	L Heilmeyer, P Friedrich
Place of Publication	AMSTERDAM
Publisher	IOS Press
Pages	334-342
Number of pages	9
ISBN (Print)	1-58603-180-5
Publication status	Published - 2001
Event	Conference of the NATO Advanced-Study-Institute on Protein Modules in Cellular Signalling - ST MARTIN DE LONDRES, France Duration: 13 Sept 2000 → 22 Sept 2000

Publication series

Name	NATO SCIENCE SERIES, SERIES A: LIFE SCIENCE
Publisher	IOS PRESS
Volume	318
ISSN (Print)	1387-6686

Conference

Conference	Conference of the NATO Advanced-Study-Institute on Protein Modules in Cellular Signalling
Country/Territory	France
Period	13/09/00 → 22/09/00

Keywords

YEAST SACCHAROMYCES-CEREVISIAE
DIACYLGLYCEROL KINASE
GLUT4-CONTAINING VESICLES
PHOSPHOINOSITIDE KINASES
PHOSPHOLIPASE-C
GOLGI-COMPLEX
RAT-LIVER
SECRETION
CLONING
PROTEIN

Cite this

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title = "The role of phosphatidylinositol 4-kinases in vesicular transport",

abstract = "Phosphoinositide metabolism is involved in signal transduction, cytoskeletal organization and in vesicular transport. The main precursor for the different phosphoinositides, phosphatidylinositol(4)phosphate (PtdIns(4)P), is synthesized by phosphatidylinositol 4-kinase (PtdIns 4-kinase). Based on biochemical characterization the family of PtdIns 4-kinases has been divided in two types (II and III). Recently, two type III isoforms of this enzyme have been cloned and sequenced. Localization studies have shown a different location for these isoforms implying different functions for the PtdIns 4-kinases in vivo. In this chapter, we review the current data about PtdIns 4-kinases, and discuss the possible physiological function of PtdIns 4-kinase activity in vesicular transport.",

keywords = "YEAST SACCHAROMYCES-CEREVISIAE, DIACYLGLYCEROL KINASE, GLUT4-CONTAINING VESICLES, PHOSPHOINOSITIDE KINASES, PHOSPHOLIPASE-C, GOLGI-COMPLEX, RAT-LIVER, SECRETION, CLONING, PROTEIN",

author = "{De Graaf}, P and AJ Verkleij and {van Bergen en Henegouwen}, PMP",

year = "2001",

language = "English",

isbn = "1-58603-180-5",

series = "NATO SCIENCE SERIES, SERIES A: LIFE SCIENCE",

publisher = "IOS Press",

pages = "334--342",

editor = "L Heilmeyer and P Friedrich",

booktitle = "PROTEIN MODULES IN CELLULAR SIGNALLING",

address = "Netherlands",

note = "Conference of the NATO Advanced-Study-Institute on Protein Modules in Cellular Signalling ; Conference date: 13-09-2000 Through 22-09-2000",

}

De Graaf, P, Verkleij, AJ & van Bergen en Henegouwen, PMP 2001, The role of phosphatidylinositol 4-kinases in vesicular transport. in L Heilmeyer & P Friedrich (eds), PROTEIN MODULES IN CELLULAR SIGNALLING. NATO SCIENCE SERIES, SERIES A: LIFE SCIENCE, vol. 318, IOS Press, AMSTERDAM, pp. 334-342, Conference of the NATO Advanced-Study-Institute on Protein Modules in Cellular Signalling, France, 13/09/00.

The role of phosphatidylinositol 4-kinases in vesicular transport. / De Graaf, P; Verkleij, AJ; van Bergen en Henegouwen, PMP.
PROTEIN MODULES IN CELLULAR SIGNALLING. ed. / L Heilmeyer; P Friedrich. AMSTERDAM: IOS Press, 2001. p. 334-342 (NATO SCIENCE SERIES, SERIES A: LIFE SCIENCE; Vol. 318).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - The role of phosphatidylinositol 4-kinases in vesicular transport

AU - De Graaf, P

AU - Verkleij, AJ

AU - van Bergen en Henegouwen, PMP

PY - 2001

Y1 - 2001

N2 - Phosphoinositide metabolism is involved in signal transduction, cytoskeletal organization and in vesicular transport. The main precursor for the different phosphoinositides, phosphatidylinositol(4)phosphate (PtdIns(4)P), is synthesized by phosphatidylinositol 4-kinase (PtdIns 4-kinase). Based on biochemical characterization the family of PtdIns 4-kinases has been divided in two types (II and III). Recently, two type III isoforms of this enzyme have been cloned and sequenced. Localization studies have shown a different location for these isoforms implying different functions for the PtdIns 4-kinases in vivo. In this chapter, we review the current data about PtdIns 4-kinases, and discuss the possible physiological function of PtdIns 4-kinase activity in vesicular transport.

AB - Phosphoinositide metabolism is involved in signal transduction, cytoskeletal organization and in vesicular transport. The main precursor for the different phosphoinositides, phosphatidylinositol(4)phosphate (PtdIns(4)P), is synthesized by phosphatidylinositol 4-kinase (PtdIns 4-kinase). Based on biochemical characterization the family of PtdIns 4-kinases has been divided in two types (II and III). Recently, two type III isoforms of this enzyme have been cloned and sequenced. Localization studies have shown a different location for these isoforms implying different functions for the PtdIns 4-kinases in vivo. In this chapter, we review the current data about PtdIns 4-kinases, and discuss the possible physiological function of PtdIns 4-kinase activity in vesicular transport.

KW - YEAST SACCHAROMYCES-CEREVISIAE

KW - DIACYLGLYCEROL KINASE

KW - GLUT4-CONTAINING VESICLES

KW - PHOSPHOINOSITIDE KINASES

KW - PHOSPHOLIPASE-C

KW - GOLGI-COMPLEX

KW - RAT-LIVER

KW - SECRETION

KW - CLONING

KW - PROTEIN

M3 - Conference contribution

SN - 1-58603-180-5

T3 - NATO SCIENCE SERIES, SERIES A: LIFE SCIENCE

SP - 334

EP - 342

BT - PROTEIN MODULES IN CELLULAR SIGNALLING

A2 - Heilmeyer, L

A2 - Friedrich, P

PB - IOS Press

CY - AMSTERDAM

T2 - Conference of the NATO Advanced-Study-Institute on Protein Modules in Cellular Signalling

Y2 - 13 September 2000 through 22 September 2000

ER -

The role of phosphatidylinositol 4-kinases in vesicular transport

Abstract

Publication series

Conference

Keywords

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