The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

J.M. Houthuijzen; L.G.M. Daenen; J.M.L. Roodhart; E.E. Voest

doi:10.1038/bjc.2012.201

The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

J.M. Houthuijzen, L.G.M. Daenen, J.M.L. Roodhart, E.E. Voest

Research output: Contribution to journal › Review article › peer-review

Abstract

It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance.

Original language	English
Pages (from-to)	1901-1906
Number of pages	6
Journal	British Journal of Cancer
Volume	106
Issue number	12
DOIs	https://doi.org/10.1038/bjc.2012.201
Publication status	Published - 5 Jun 2012

Keywords

Animals
Cell Differentiation
Disease Progression
Drug Resistance, Neoplasm
Humans
Mesenchymal Stem Cells/drug effects
Neoplastic Stem Cells
Tumor Microenvironment

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10.1038/bjc.2012.201

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title = "The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression",

abstract = "It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance.",

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AU - Houthuijzen, J.M.

AU - Daenen, L.G.M.

AU - Roodhart, J.M.L.

AU - Voest, E.E.

PY - 2012/6/5

Y1 - 2012/6/5

N2 - It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance.

AB - It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance.

KW - Animals

KW - Cell Differentiation

KW - Disease Progression

KW - Drug Resistance, Neoplasm

KW - Humans

KW - Mesenchymal Stem Cells/drug effects

KW - Neoplastic Stem Cells

KW - Tumor Microenvironment

U2 - 10.1038/bjc.2012.201

DO - 10.1038/bjc.2012.201

M3 - Review article

C2 - 22596239

SN - 0007-0920

VL - 106

SP - 1901

EP - 1906

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 12

ER -

The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

Abstract

Keywords

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