TY - JOUR
T1 - The role of melatonin treatment in chronic kidney disease.
AU - Russcher, Marije
AU - Koch, Birgit C. P.
AU - Nagtegaal, J. Elsbeth
AU - van der Putten, Karien
AU - Wee, Pietter
AU - Gaillard, Carlo
N1 - Russcher, Marije Koch, Birgit Nagtegaal, Elsbeth van der Putten, Karien Ter Wee, Piet Gaillard, Carlo Front Biosci. 2012 Jun 1;17:2644-56.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.
AB - The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.
KW - 24-hour blood pressure
KW - Chronic kidney disease
KW - Hemodialysis
KW - Melatonin
KW - Oxidative stress
KW - Review
KW - Sleep disturbances
UR - http://www.scopus.com/inward/record.url?scp=84860279536&partnerID=8YFLogxK
U2 - 10.2741/4075
DO - 10.2741/4075
M3 - Article
C2 - 22652802
SN - 1093-9946
VL - 17
SP - 2644
EP - 2656
JO - Frontiers in Bioscience-Landmark
JF - Frontiers in Bioscience-Landmark
IS - 7
ER -