The role of heterochromatin in 3D genome organization during preimplantation development

Franka J. Rang; Jop Kind; Isabel Guerreiro

doi:10.1016/j.celrep.2023.112248

The role of heterochromatin in 3D genome organization during preimplantation development

Franka J. Rang, Jop Kind^*, Isabel Guerreiro^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.

Original language	English
Article number	112248
Journal	Cell Reports
Volume	42
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2023.112248
Publication status	Published - 25 Apr 2023

Keywords

CP: Developmental biology
CP: Molecular biology

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10.1016/j.celrep.2023.112248Licence: CC BY-NC-ND

1-s2.0-S2211124723002590-mainFinal published version, 2.07 MBLicence: CC BY-NC-ND

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title = "The role of heterochromatin in 3D genome organization during preimplantation development",

abstract = "During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.",

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AU - Rang, Franka J.

AU - Kind, Jop

AU - Guerreiro, Isabel

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Y1 - 2023/4/25

N2 - During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.

AB - During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.

KW - CP: Developmental biology

KW - CP: Molecular biology

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DO - 10.1016/j.celrep.2023.112248

M3 - Review article

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SN - 2211-1247

VL - 42

JO - Cell Reports

JF - Cell Reports

IS - 4

M1 - 112248

ER -

The role of heterochromatin in 3D genome organization during preimplantation development

Abstract

Keywords

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