The role of activation status of circulating neutrophils in the injured patient

K.M. Groeneveld

The role of activation status of circulating neutrophils in the injured patient

K.M. Groeneveld

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

This thesis describes the complex role of the neutrophil responses after injuries

are sustained. Depending on the severity of the injuries, neutrophil activity could

be found on a sliding scale starting with functionally active on one side, and

refractory on the other, leading to severe inflammatory complications. Early

intervention in high-risk patient populations using novel therapeutic strategies

derived from our improved understanding of innate mediators of tissue injury,

can reduce the incidence and prevalence of detrimental infectious complications,

prolonged Intensive Care Unit usage and hospital stay and ameliorate associated

healthcare costs.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Leenen, Loek, Primary supervisor Koenderman, Leo, Supervisor Hietbrink, F., Co-supervisor
Award date	30 Aug 2018
Publisher	Utrecht University
Print ISBNs	978-946-323-31-87
Publication status	Published - 30 Aug 2018

Keywords

trauma
neutrophil
sepsis
burns
shock
systemic inflammation
injury

Cite this

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title = "The role of activation status of circulating neutrophils in the injured patient",

abstract = "This thesis describes the complex role of the neutrophil responses after injuriesare sustained. Depending on the severity of the injuries, neutrophil activity couldbe found on a sliding scale starting with functionally active on one side, andrefractory on the other, leading to severe inflammatory complications. Earlyintervention in high-risk patient populations using novel therapeutic strategiesderived from our improved understanding of innate mediators of tissue injury,can reduce the incidence and prevalence of detrimental infectious complications,prolonged Intensive Care Unit usage and hospital stay and ameliorate associatedhealthcare costs.",

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N2 - This thesis describes the complex role of the neutrophil responses after injuriesare sustained. Depending on the severity of the injuries, neutrophil activity couldbe found on a sliding scale starting with functionally active on one side, andrefractory on the other, leading to severe inflammatory complications. Earlyintervention in high-risk patient populations using novel therapeutic strategiesderived from our improved understanding of innate mediators of tissue injury,can reduce the incidence and prevalence of detrimental infectious complications,prolonged Intensive Care Unit usage and hospital stay and ameliorate associatedhealthcare costs.

AB - This thesis describes the complex role of the neutrophil responses after injuriesare sustained. Depending on the severity of the injuries, neutrophil activity couldbe found on a sliding scale starting with functionally active on one side, andrefractory on the other, leading to severe inflammatory complications. Earlyintervention in high-risk patient populations using novel therapeutic strategiesderived from our improved understanding of innate mediators of tissue injury,can reduce the incidence and prevalence of detrimental infectious complications,prolonged Intensive Care Unit usage and hospital stay and ameliorate associatedhealthcare costs.

KW - trauma

KW - neutrophil

KW - sepsis

KW - burns

KW - shock

KW - systemic inflammation

KW - injury

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-946-323-31-87

PB - Utrecht University

ER -

The role of activation status of circulating neutrophils in the injured patient

Abstract

Keywords

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