The risk of second primary tumors in head and neck cancer: A systematic review

Andrés Coca-Pelaz; Juan P Rodrigo; Carlos Suárez; Iain J Nixon; Antti Mäkitie; Alvaro Sanabria; Miquel Quer; Primož Strojan; Carol R Bradford; Luiz P Kowalski; Ashok R Shaha; Remco de Bree; Dana M Hartl; Alessandra Rinaldo; Robert P Takes; Alfio Ferlito

doi:10.1002/hed.26016

The risk of second primary tumors in head and neck cancer: A systematic review

Andrés Coca-Pelaz, Juan P Rodrigo, Carlos Suárez, Iain J Nixon, Antti Mäkitie, Alvaro Sanabria, Miquel Quer, Primož Strojan, Carol R Bradford, Luiz P Kowalski, Ashok R Shaha, Remco de Bree, Dana M Hartl, Alessandra Rinaldo, Robert P Takes, Alfio Ferlito

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up.

METHODS: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population.

RESULTS: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus.

CONCLUSION: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

Original language	English
Pages (from-to)	456-466
Number of pages	11
Journal	Head & neck
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/hed.26016
Publication status	Published - Mar 2020

Keywords

head and neck cancer
metachronous
second primary tumor
squamous cell carcinoma
synchronous

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10.1002/hed.26016

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Coca-Pelaz, A., Rodrigo, J. P., Suárez, C., Nixon, I. J., Mäkitie, A., Sanabria, A., Quer, M., Strojan, P., Bradford, C. R., Kowalski, L. P., Shaha, A. R., de Bree, R., Hartl, D. M., Rinaldo, A., Takes, R. P., & Ferlito, A. (2020). The risk of second primary tumors in head and neck cancer: A systematic review. Head & neck, 42(3), 456-466. https://doi.org/10.1002/hed.26016

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abstract = "BACKGROUND: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up.METHODS: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population.RESULTS: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus.CONCLUSION: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.",

keywords = "head and neck cancer, metachronous, second primary tumor, squamous cell carcinoma, synchronous",

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year = "2020",

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doi = "10.1002/hed.26016",

language = "English",

volume = "42",

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T2 - A systematic review

AU - Coca-Pelaz, Andrés

AU - Rodrigo, Juan P

AU - Suárez, Carlos

AU - Nixon, Iain J

AU - Mäkitie, Antti

AU - Sanabria, Alvaro

AU - Quer, Miquel

AU - Strojan, Primož

AU - Bradford, Carol R

AU - Kowalski, Luiz P

AU - Shaha, Ashok R

AU - de Bree, Remco

AU - Hartl, Dana M

AU - Rinaldo, Alessandra

AU - Takes, Robert P

AU - Ferlito, Alfio

PY - 2020/3

Y1 - 2020/3

N2 - BACKGROUND: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up.METHODS: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population.RESULTS: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus.CONCLUSION: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

AB - BACKGROUND: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up.METHODS: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population.RESULTS: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus.CONCLUSION: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

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The risk of second primary tumors in head and neck cancer: A systematic review

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