The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

Willem Verpoest; Sara Seneca; Marjan De Rademaeker; Karen Sermon; Martine De Rycke; Michel De Vos; Patrick Haentjens; Paul Devroey; Ingeborg Liebaers

doi:10.1007/s10815-010-9392-9

The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

Willem Verpoest^*, Sara Seneca, Marjan De Rademaeker, Karen Sermon, Martine De Rycke, Michel De Vos, Patrick Haentjens, Paul Devroey, Ingeborg Liebaers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.

METHODS: Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.

RESULTS: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).

CONCLUSION: There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

Original language	English
Pages (from-to)	327-333
Number of pages	7
Journal	Journal of Assisted Reproduction and Genetics
Volume	27
Issue number	6
DOIs	https://doi.org/10.1007/s10815-010-9392-9
Publication status	Published - Jun 2010
Externally published	Yes

Keywords

Female
Humans
Male
Myotonic Dystrophy/genetics
Pregnancy
Pregnancy Outcome/genetics
Preimplantation Diagnosis
Prospective Studies
Sperm Injections, Intracytoplasmic
Trinucleotide Repeat Expansion
Trinucleotide Repeats

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Verpoest, W., Seneca, S., De Rademaeker, M., Sermon, K., De Rycke, M., De Vos, M., Haentjens, P., Devroey, P., & Liebaers, I. (2010). The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract. Journal of Assisted Reproduction and Genetics, 27(6), 327-333. https://doi.org/10.1007/s10815-010-9392-9

@article{aee5007fbffa4b5daaa4b7c92d1646ac,

title = "The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract",

abstract = "PURPOSE: This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.METHODS: Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.RESULTS: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).CONCLUSION: There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.",

keywords = "Female, Humans, Male, Myotonic Dystrophy/genetics, Pregnancy, Pregnancy Outcome/genetics, Preimplantation Diagnosis, Prospective Studies, Sperm Injections, Intracytoplasmic, Trinucleotide Repeat Expansion, Trinucleotide Repeats",

author = "Willem Verpoest and Sara Seneca and {De Rademaeker}, Marjan and Karen Sermon and {De Rycke}, Martine and {De Vos}, Michel and Patrick Haentjens and Paul Devroey and Ingeborg Liebaers",

year = "2010",

month = jun,

doi = "10.1007/s10815-010-9392-9",

language = "English",

volume = "27",

pages = "327--333",

journal = "Journal of Assisted Reproduction and Genetics",

issn = "1058-0468",

publisher = "Springer New York",

number = "6",

}

Verpoest, W, Seneca, S, De Rademaeker, M, Sermon, K, De Rycke, M, De Vos, M, Haentjens, P, Devroey, P & Liebaers, I 2010, 'The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract', Journal of Assisted Reproduction and Genetics, vol. 27, no. 6, pp. 327-333. https://doi.org/10.1007/s10815-010-9392-9

The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract. / Verpoest, Willem; Seneca, Sara; De Rademaeker, Marjan et al.
In: Journal of Assisted Reproduction and Genetics, Vol. 27, No. 6, 06.2010, p. 327-333.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

AU - Verpoest, Willem

AU - Seneca, Sara

AU - De Rademaeker, Marjan

AU - Sermon, Karen

AU - De Rycke, Martine

AU - De Vos, Michel

AU - Haentjens, Patrick

AU - Devroey, Paul

AU - Liebaers, Ingeborg

PY - 2010/6

Y1 - 2010/6

N2 - PURPOSE: This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.METHODS: Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.RESULTS: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).CONCLUSION: There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

AB - PURPOSE: This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.METHODS: Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.RESULTS: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).CONCLUSION: There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

KW - Female

KW - Humans

KW - Male

KW - Myotonic Dystrophy/genetics

KW - Pregnancy

KW - Pregnancy Outcome/genetics

KW - Preimplantation Diagnosis

KW - Prospective Studies

KW - Sperm Injections, Intracytoplasmic

KW - Trinucleotide Repeat Expansion

KW - Trinucleotide Repeats

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DO - 10.1007/s10815-010-9392-9

M3 - Article

C2 - 20221684

SN - 1058-0468

VL - 27

SP - 327

EP - 333

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

IS - 6

ER -

The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

Abstract

Keywords

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