TY - GEN
T1 - The Relative Impact of Urinary and Sexual Function vs Bother on Health Utility for Men With Prostate Cancer
AU - Jeong, Chang Wook
AU - Herlemann, Annika
AU - Cowan, Janet E.
AU - Broering, Jeanette M.
AU - ten Ham, Renske M. T.
AU - Wilson, Leslie S.
AU - Carroll, Peter R.
AU - Cooperberg, Matthew R.
N1 - Funding Information:
CaPSURE was funded until 2007 by TAP Pharmaceutical Products Inc. It is currently funded by US Department of Defense grant W81XWH-13-2-0074 and the University of California, San Francisco, Department of Urology. This study was also partly supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (HA17C0039).
Publisher Copyright:
© The Author(s) 2020.
PY - 2021
Y1 - 2021
N2 - Function and bother are related but distinct aspects of health-related quality of life. The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of health-related quality of life in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1617 men. Linear regression on the patients' function and bother summary scores (0-100) from the University of California, Los Angeles Prostate Cancer Index was performed to predict bias-corrected health utilities. Urinary and sexual bother were associated with each health utility, and their coefficients were 3.7 and 20.8 times greater, respectively, than those of the corresponding function. To our knowledge, our study provides the first quantitative and direct comparison of the impacts of function vs bother on health utility.
AB - Function and bother are related but distinct aspects of health-related quality of life. The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of health-related quality of life in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1617 men. Linear regression on the patients' function and bother summary scores (0-100) from the University of California, Los Angeles Prostate Cancer Index was performed to predict bias-corrected health utilities. Urinary and sexual bother were associated with each health utility, and their coefficients were 3.7 and 20.8 times greater, respectively, than those of the corresponding function. To our knowledge, our study provides the first quantitative and direct comparison of the impacts of function vs bother on health utility.
UR - http://www.scopus.com/inward/record.url?scp=85100606312&partnerID=8YFLogxK
U2 - 10.1093/JNCICS/PKAA044
DO - 10.1093/JNCICS/PKAA044
M3 - Other contribution
C2 - 33134826
VL - 4
T3 - JNCI cancer spectrum
ER -