@article{7e85ea8ce20d4b8ab5871220d9df1358,
title = "The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study",
abstract = "This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.",
keywords = "Childhood adversity, Cognition, Family history of psychosis, First episode, Polygenic risk score, Psychosis",
author = "Lucia Sideli and Monica Aas and Diego Quattrone and {La Barbera}, Daniele and {La Cascia}, Caterina and Laura Ferraro and Luis Alameda and Eva Velthorst and Giulia Trotta and Giada Tripoli and Adriano Schimmenti and Andrea Fontana and Charlotte Gayer-Anderson and Simona Stilo and Fabio Seminerio and Crocettarachele Sartorio and Giovanna Marrazzo and Antonio Lasalvia and Sarah Tosato and Ilaria Tarricone and Domenico Berardi and Giuseppe D'Andrea and Celso Arango and Manuel Arrojo and Miguel Bernardo and Julio Bobes and Julio Sanju{\'a}n and Santos, {Jose Luis} and Menezes, {Paulo Rossi} and Del-Ben, {Cristina Marta} and Jongsma, {Hannah E} and Jones, {Peter B} and Kirkbride, {James B} and Pierre-Michel Llorca and Andrea Tortelli and Baptiste Pignon and {de Haan}, Lieuwe and Jean-Paul Selten and {Van Os}, Jim and Rutten, {Bart P} and Richard Bentall and {Di Forti}, Marta and Murray, {Robin M} and Craig Morgan and Fisher, {Helen L}",
note = "Funding Information: We are grateful to the EU-GEI study participants for their essential contribution to this project. The EU-GEI Study is funded by grant agreement HEALTH-F2-2010–241909 (Project EU-GEI) from the European Community{\textquoteright}s Seventh Framework Programme, and Grant 2012/0417–0 from the S{\~a}o Paulo Research Foundation. B.P.F. Rutten is funded by a VIDI award (no. 91.718.336) from the Netherlands Scientific Organization. H. L. Fisher, C. Gayer-Anderson, and C. Morgan are supported by the Economic and Social Research Council (ESRC) Centre for Society and Mental Health at King{\textquoteright}s College London [ES/S012567/1]. D. Quattrone is supported by the Medical Research Council Clinical Academic Research Partnership [MR/W030608/1]. M. Aas is supported by an MRC fellowship (#MR/WO27720/1). C. Arango has received support from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (ISCIII), co-financed by the European Union, ERDF Funds from the European Commission, “A way of making Europe”, financed by the European Union—NextGenerationEU (PMP21/00051, PI19/01024), CIBERSAM, Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds, European Union Seventh Framework Program, European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2 (Grant agreement No.101034377), Project AIMS-2-TRIALS (Grant agreement No 777394), Horizon Europe, the National Institute of Mental Health of the National Institutes of Health under Award Number 1U01MH124639-01 (Project ProNET) and Award Number 5P50MH115846-03 (Project FEP-CAUSAL), Fundaci{\'o}n Familia Alonso, and Fundaci{\'o}n Alicia Koplowitz. The views expressed are those of the authors and not necessarily those of the ESRC or King{\textquoteright}s College London. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = oct,
doi = "10.1007/s00127-023-02513-0",
language = "English",
volume = "58",
pages = "1573--1580",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "D. Steinkopff-Verlag",
number = "10",
}