The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children

J.G.C. van Amsterdam; N.A. Janssen; G. de Meer; P.H. Fischer; S. Nierkens; H. van Loveren; A. Opperhuizen; P.A. Steerenberg; B. Brunekreef

doi:10.1046/j.1365-2222.2003.01597.x

The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children

J.G.C. van Amsterdam, N.A. Janssen, G. de Meer, P.H. Fischer, S. Nierkens, H. van Loveren, A. Opperhuizen, P.A. Steerenberg, B. Brunekreef

Julius Center, dept. Epidemiology & Health Economics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Exhaled nitric oxide (NO) has been proposed as novel a non-invasive marker of airway inflammation.

OBJECTIVE: The level of exhaled NO was determined in a random sample of school children (7-12 years old) with the aim of investigating the relationship between exhaled NO and sensitization to common allergens.

RESULTS: In the 450 children tested by skin prick tests (SPT), the prevalence of sensitization was 29.5% (overall), 21.9% (sensitization to indoor allergens), and 15.0% (sensitization to outdoor allergens). Regression analysis showed that levels of exhaled nitric oxide were closely associated with various measures of sensitization to aeroallergens. Sensitization to indoor allergens was associated with higher levels of exhaled NO (eNO) than sensitization to outdoor allergens when assessed by IgE but not when assessed by SPT. Children with reported wheeze in the past 12 months had much stronger associations between sensitization and eNO than children without wheeze.

CONCLUSION: We conclude that allergic sensitization is strongly associated with increased levels of exhaled NO, especially in children with wheeze.

Original language	English
Pages (from-to)	187-191
Number of pages	5
Journal	Clinical and Experimental Allergy
Volume	33
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2222.2003.01597.x
Publication status	Published - Feb 2003

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van Amsterdam, J. G. C., Janssen, N. A., de Meer, G., Fischer, P. H., Nierkens, S., van Loveren, H., Opperhuizen, A., Steerenberg, P. A., & Brunekreef, B. (2003). The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children. Clinical and Experimental Allergy, 33(2), 187-191. https://doi.org/10.1046/j.1365-2222.2003.01597.x

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title = "The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children",

abstract = "BACKGROUND: Exhaled nitric oxide (NO) has been proposed as novel a non-invasive marker of airway inflammation.OBJECTIVE: The level of exhaled NO was determined in a random sample of school children (7-12 years old) with the aim of investigating the relationship between exhaled NO and sensitization to common allergens.RESULTS: In the 450 children tested by skin prick tests (SPT), the prevalence of sensitization was 29.5% (overall), 21.9% (sensitization to indoor allergens), and 15.0% (sensitization to outdoor allergens). Regression analysis showed that levels of exhaled nitric oxide were closely associated with various measures of sensitization to aeroallergens. Sensitization to indoor allergens was associated with higher levels of exhaled NO (eNO) than sensitization to outdoor allergens when assessed by IgE but not when assessed by SPT. Children with reported wheeze in the past 12 months had much stronger associations between sensitization and eNO than children without wheeze.CONCLUSION: We conclude that allergic sensitization is strongly associated with increased levels of exhaled NO, especially in children with wheeze.",

author = "{van Amsterdam}, J.G.C. and N.A. Janssen and {de Meer}, G. and P.H. Fischer and S. Nierkens and {van Loveren}, H. and A. Opperhuizen and P.A. Steerenberg and B. Brunekreef",

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doi = "10.1046/j.1365-2222.2003.01597.x",

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AU - van Amsterdam, J.G.C.

AU - Janssen, N.A.

AU - de Meer, G.

AU - Fischer, P.H.

AU - Nierkens, S.

AU - van Loveren, H.

AU - Opperhuizen, A.

AU - Steerenberg, P.A.

AU - Brunekreef, B.

PY - 2003/2

Y1 - 2003/2

N2 - BACKGROUND: Exhaled nitric oxide (NO) has been proposed as novel a non-invasive marker of airway inflammation.OBJECTIVE: The level of exhaled NO was determined in a random sample of school children (7-12 years old) with the aim of investigating the relationship between exhaled NO and sensitization to common allergens.RESULTS: In the 450 children tested by skin prick tests (SPT), the prevalence of sensitization was 29.5% (overall), 21.9% (sensitization to indoor allergens), and 15.0% (sensitization to outdoor allergens). Regression analysis showed that levels of exhaled nitric oxide were closely associated with various measures of sensitization to aeroallergens. Sensitization to indoor allergens was associated with higher levels of exhaled NO (eNO) than sensitization to outdoor allergens when assessed by IgE but not when assessed by SPT. Children with reported wheeze in the past 12 months had much stronger associations between sensitization and eNO than children without wheeze.CONCLUSION: We conclude that allergic sensitization is strongly associated with increased levels of exhaled NO, especially in children with wheeze.

AB - BACKGROUND: Exhaled nitric oxide (NO) has been proposed as novel a non-invasive marker of airway inflammation.OBJECTIVE: The level of exhaled NO was determined in a random sample of school children (7-12 years old) with the aim of investigating the relationship between exhaled NO and sensitization to common allergens.RESULTS: In the 450 children tested by skin prick tests (SPT), the prevalence of sensitization was 29.5% (overall), 21.9% (sensitization to indoor allergens), and 15.0% (sensitization to outdoor allergens). Regression analysis showed that levels of exhaled nitric oxide were closely associated with various measures of sensitization to aeroallergens. Sensitization to indoor allergens was associated with higher levels of exhaled NO (eNO) than sensitization to outdoor allergens when assessed by IgE but not when assessed by SPT. Children with reported wheeze in the past 12 months had much stronger associations between sensitization and eNO than children without wheeze.CONCLUSION: We conclude that allergic sensitization is strongly associated with increased levels of exhaled NO, especially in children with wheeze.

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DO - 10.1046/j.1365-2222.2003.01597.x

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VL - 33

SP - 187

EP - 191

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

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ER -

The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children

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