TY - JOUR
T1 - The relationship between early life EEG and brain MRI in preterm infants
T2 - A systematic review
AU - Meijer, Roos F.
AU - Wang, Xiaowan
AU - van Ooijen, Inge M.
AU - van der Velde, Bauke
AU - Dudink, Jeroen
AU - Benders, Manon J.N.L.
AU - Tataranno, Maria Luisa
N1 - Publisher Copyright:
© 2024 International Federation of Clinical Neurophysiology
PY - 2025/2
Y1 - 2025/2
N2 - Objective: To systematically review the literature on the associations between electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) measures in preterm infants (gestational age < 37 weeks). Methods: A comprehensive search was performed in PubMed and EMBASE databases up to February 12th, 2024. Non-relevant studies were eliminated following the PRISMA guidelines. Results: Ten out of 991 identified studies were included. Brain MRI metrics used in these studies include volumes, cortical features, microstructural integrity, visual assessments, and cerebral linear measurements. EEG parameters were classified as qualitative (Burdjalov maturity score, seizure burden, and background activity) or quantitative (discontinuity, spectral content, amplitude, and connectivity). Among them, discontinuity and the Burdjalov score were most frequently examined. Higher discontinuity was associated with reduced brain volume, cortical surface, microstructural integrity, and linear measurements. The Burdjalov score related to brain maturation qualitatively assessed on MRI. No other consistent correlations could be established due to the variability across studies. Conclusions: The reviewed studies utilized a variety of EEG and MRI measurements, while discontinuity and the Burdjalov score stood out as significant indicators of structural brain development. Significance: This review, for the first time, provides an extensive overview of EEG-MRI associations in preterm infants, potentially facilitating their clinical application.
AB - Objective: To systematically review the literature on the associations between electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) measures in preterm infants (gestational age < 37 weeks). Methods: A comprehensive search was performed in PubMed and EMBASE databases up to February 12th, 2024. Non-relevant studies were eliminated following the PRISMA guidelines. Results: Ten out of 991 identified studies were included. Brain MRI metrics used in these studies include volumes, cortical features, microstructural integrity, visual assessments, and cerebral linear measurements. EEG parameters were classified as qualitative (Burdjalov maturity score, seizure burden, and background activity) or quantitative (discontinuity, spectral content, amplitude, and connectivity). Among them, discontinuity and the Burdjalov score were most frequently examined. Higher discontinuity was associated with reduced brain volume, cortical surface, microstructural integrity, and linear measurements. The Burdjalov score related to brain maturation qualitatively assessed on MRI. No other consistent correlations could be established due to the variability across studies. Conclusions: The reviewed studies utilized a variety of EEG and MRI measurements, while discontinuity and the Burdjalov score stood out as significant indicators of structural brain development. Significance: This review, for the first time, provides an extensive overview of EEG-MRI associations in preterm infants, potentially facilitating their clinical application.
KW - Brain maturation
KW - EEG
KW - MRI
KW - Preterm infants
UR - http://www.scopus.com/inward/record.url?scp=85213203226&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2024.12.014
DO - 10.1016/j.clinph.2024.12.014
M3 - Article
AN - SCOPUS:85213203226
SN - 1388-2457
VL - 170
SP - 168
EP - 179
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -