The rabbit model in preclinical hypospadias research: Strengths and limitations

Tariq Abbas; Petra De Graaf; Cristian Pablo Pennisi

doi:10.1007/978-981-19-7666-7_3

The rabbit model in preclinical hypospadias research: Strengths and limitations

Tariq Abbas^*, Petra De Graaf, Cristian Pablo Pennisi

^*Corresponding author for this work

Regenerative Medicine and Stem Cells

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The rabbit model is widely used to evaluate routine urethroplasty procedures and also to test new tissue engineering approaches for the treatment of hypospadias. The overall goal is to evaluate long-term structural and functional effects prior to clinical application, but advances in this area must be balanced against the need to replace, reduce, and refine the use of animals in research. To ensure translatability and reproducibility, some of the most critical issues to define when designing preclinical studies of hypospadias are animal age, anatomic location, and injury size. Importantly, future research strategies should consider new methods for assessing functional performance and models that approximate human pathology. (See Video 3.1).

Original language	English
Title of host publication	Hypospadiology
Subtitle of host publication	Current Challenges and Future Perspectives
Publisher	Springer Nature
Chapter	3
Pages	37-52
Number of pages	16
ISBN (Electronic)	9789811976667
ISBN (Print)	9789811976650
DOIs	https://doi.org/10.1007/978-981-19-7666-7_3
Publication status	Published - 29 Jun 2023

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The rabbit model in preclinical hypospadias research: Strengths and limitations

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