The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

W. de Lau; W.C. Peng; P. Gros; H.C. Clevers

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Translated title of the contribution: The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

W. de Lau
, W.C. Peng
, P. Gros
, H.C. Clevers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists

Translated title of the contribution	The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
Original language	Undefined/Unknown
Pages (from-to)	305-316
Number of pages	12
Journal	Genes and Development
Volume	28
Issue number	4
Publication status	Published - 2014

Cite this

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title = "The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength",

abstract = "Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists",

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note = "J EB 15 2014",

year = "2014",

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pages = "305--316",

journal = "Genes and Development",

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publisher = "Cold Spring Harbor Laboratory Press",

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TY - JOUR

T1 - The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

AU - de Lau, W.

AU - Peng, W.C.

AU - Gros, P.

AU - Clevers, H.C.

N1 - J EB 15 2014

PY - 2014

Y1 - 2014

N2 - Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists

AB - Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists

M3 - Article

SN - 0890-9369

VL - 28

SP - 305

EP - 316

JO - Genes and Development

JF - Genes and Development

IS - 4

ER -

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Abstract

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