Abstract
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists
| Translated title of the contribution | The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | 305-316 |
| Number of pages | 12 |
| Journal | Genes and Development |
| Volume | 28 |
| Issue number | 4 |
| Publication status | Published - 2014 |