The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1

Elly M Hol; Fred W van Leeuwen; David F Fischer

doi:10.1016/j.molmed.2005.09.001

The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1

Elly M Hol, Fred W van Leeuwen, David F Fischer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ubiquitin-containing cellular inclusions are characteristic of major neurodegenerative diseases and suggest an involvement of the ubiquitin-proteasome system. The frameshifted form of ubiquitin has proved to be a valuable tool for studying the role of the ubiquitin-proteasome system. It is an endogenous reporter for proteasome activity in human pathology but it is also capable of inhibiting proteasomal degradation. Current studies have revealed that the frameshifted form of ubiquitin accumulates in the brains of patients with Alzheimer's disease but not in those with Parkinson's disease.

Original language	English
Pages (from-to)	488-95
Number of pages	8
Journal	Trends in molecular medicine
Volume	11
Issue number	11
DOIs	https://doi.org/10.1016/j.molmed.2005.09.001
Publication status	Published - Nov 2005

Keywords

Alzheimer Disease
Frameshift Mutation
Genes, Reporter
Humans
Inclusion Bodies
Models, Biological
Parkinson Disease
Proteasome Endopeptidase Complex
Ubiquitin
Journal Article
Research Support, Non-U.S. Gov't
Review

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10.1016/j.molmed.2005.09.001

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title = "The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1",

abstract = "Ubiquitin-containing cellular inclusions are characteristic of major neurodegenerative diseases and suggest an involvement of the ubiquitin-proteasome system. The frameshifted form of ubiquitin has proved to be a valuable tool for studying the role of the ubiquitin-proteasome system. It is an endogenous reporter for proteasome activity in human pathology but it is also capable of inhibiting proteasomal degradation. Current studies have revealed that the frameshifted form of ubiquitin accumulates in the brains of patients with Alzheimer's disease but not in those with Parkinson's disease.",

keywords = "Alzheimer Disease, Frameshift Mutation, Genes, Reporter, Humans, Inclusion Bodies, Models, Biological, Parkinson Disease, Proteasome Endopeptidase Complex, Ubiquitin, Journal Article, Research Support, Non-U.S. Gov't, Review",

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year = "2005",

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doi = "10.1016/j.molmed.2005.09.001",

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AU - van Leeuwen, Fred W

AU - Fischer, David F

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AB - Ubiquitin-containing cellular inclusions are characteristic of major neurodegenerative diseases and suggest an involvement of the ubiquitin-proteasome system. The frameshifted form of ubiquitin has proved to be a valuable tool for studying the role of the ubiquitin-proteasome system. It is an endogenous reporter for proteasome activity in human pathology but it is also capable of inhibiting proteasomal degradation. Current studies have revealed that the frameshifted form of ubiquitin accumulates in the brains of patients with Alzheimer's disease but not in those with Parkinson's disease.

KW - Alzheimer Disease

KW - Frameshift Mutation

KW - Genes, Reporter

KW - Humans

KW - Inclusion Bodies

KW - Models, Biological

KW - Parkinson Disease

KW - Proteasome Endopeptidase Complex

KW - Ubiquitin

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

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DO - 10.1016/j.molmed.2005.09.001

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SP - 488

EP - 495

JO - Trends in molecular medicine

JF - Trends in molecular medicine

IS - 11

ER -

The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1

Abstract

Keywords

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