The prevention of peridural adhesions: A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft

Jaap J. Quist; Wouter J.A. Dhert; Björn P. Meij; Walter J. Visser; F. Cumhur Oner; Herman A.W. Hazewinkel; Abraham J. Verbeut

doi:10.1302/0301-620X.80B3.8010

The prevention of peridural adhesions: A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft

Jaap J. Quist
, Wouter J.A. Dhert^*
, Björn P. Meij
, Walter J. Visser
, F. Cumhur Oner
, Herman A.W. Hazewinkel
, Abraham J. Verbeut

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PET) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks. Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue. We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.

Original language	English
Pages (from-to)	520-526
Number of pages	7
Journal	Journal of Bone and Joint Surgery (Br)
Volume	80
Issue number	3
DOIs	https://doi.org/10.1302/0301-620X.80B3.8010
Publication status	Published - May 1998

Keywords

Econometric and Statistical Methods: General
Geneeskunde(GENK)
Algemeen onderzoek
Surgery

Access to Document

10.1302/0301-620X.80B3.8010

Cite this

@article{11dbeb1a594c4a0295a2c77936b6d28b,

title = "The prevention of peridural adhesions: A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft",

abstract = "We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PET) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks. Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue. We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.",

keywords = "Econometric and Statistical Methods: General, Geneeskunde(GENK), Algemeen onderzoek, Surgery",

author = "Quist, \{Jaap J.\} and Dhert, \{Wouter J.A.\} and Meij, \{Bj{\"o}rn P.\} and Visser, \{Walter J.\} and Oner, \{F. Cumhur\} and Hazewinkel, \{Herman A.W.\} and Verbeut, \{Abraham J.\}",

year = "1998",

month = may,

doi = "10.1302/0301-620X.80B3.8010",

language = "English",

volume = "80",

pages = "520--526",

journal = "Journal of Bone and Joint Surgery (Br)",

issn = "0301-620X",

publisher = "British Editorial Society of Bone and Joint Surgery",

number = "3",

}

TY - JOUR

T1 - The prevention of peridural adhesions

T2 - A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft

AU - Quist, Jaap J.

AU - Dhert, Wouter J.A.

AU - Meij, Björn P.

AU - Visser, Walter J.

AU - Oner, F. Cumhur

AU - Hazewinkel, Herman A.W.

AU - Verbeut, Abraham J.

PY - 1998/5

Y1 - 1998/5

N2 - We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PET) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks. Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue. We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.

AB - We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PET) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks. Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue. We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.

KW - Econometric and Statistical Methods: General

KW - Geneeskunde(GENK)

KW - Algemeen onderzoek

KW - Surgery

UR - https://www.scopus.com/pages/publications/0031745349

U2 - 10.1302/0301-620X.80B3.8010

DO - 10.1302/0301-620X.80B3.8010

M3 - Article

C2 - 9619950

SN - 0301-620X

VL - 80

SP - 520

EP - 526

JO - Journal of Bone and Joint Surgery (Br)

JF - Journal of Bone and Joint Surgery (Br)

IS - 3

ER -

The prevention of peridural adhesions: A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this