The premenopausal breast cancer collaboration: A pooling project of studies participating in the national cancer institute cohort consortium

Hazel B. Nichols*, Minouk J. Schoemaker, Lauren B. Wright, Craig McGowan, Mark N. Brook, Kathleen M. Mcclain, Michael E Jones, Hans-Olov Adami, Claudia Agnoli, Laura Baglietto, Leslie Bernstein, Kimberly A Bertrand, William J. Blot, Marie Christine Boutron-Ruault, Lesley M Butler, Kuan-Yu Chen, Michele M. Doody, Laure Dossus, A. Heather Eliassen, Graham G. GilesInger T. Gram, Susan E. Hankinson, Judy Hoffman-Bolton, Rudolf Kaaks, Timothy J. Key, Victoria A. Kirsh, Cari M Kitahara, Woon-Puay Koh, Susanna C. Larsson, Eiliv Lund, Huiyan Ma, Melissa A. Merritt, Roger L. Milne, Carmen Navarro, Kim Overvad, Kotaro Ozasa, Julie R. Palmer, Petra H. Peeters, Elio Riboli, Thomas E. Rohan, Atsuko Sadakane, Malin Sund, Rulla M Tamimi, Antonia Trichopoulou, Lars Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter C. Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Wei Zheng, Dale P Sandler, Anthony J. Swerdlow

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individuallevel data from studies participating in the United States National Cancer Institute Cohort Consortium. This article describes the Group, including the rationale for its initial aims related to pregnancy, obesity, and physical activity. We also describe the 20 cohort studies with data submitted to the Group by June 2016. The infrastructure developed for this work can be leveraged to support additional investigations.

Original languageEnglish
Pages (from-to)1360-1369
Number of pages10
JournalCancer Epidemiology Biomarkers & Prevention
Volume26
Issue number9
DOIs
Publication statusPublished - 1 Sept 2017

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