TY - JOUR
T1 - The Non-Invasive Diagnosis of Chronic Coronary Syndrome
T2 - A Focus on Stress Computed Tomography Perfusion and Stress Cardiac Magnetic Resonance
AU - Groenhoff, Léon
AU - De Zan, Giulia
AU - Costantini, Pietro
AU - Siani, Agnese
AU - Ostillio, Eleonora
AU - Carriero, Serena
AU - Muscogiuri, Giuseppe
AU - Bergamaschi, Luca
AU - Patti, Giuseppe
AU - Pizzi, Carmine
AU - Sironi, Sandro
AU - Pavon, Anna Giulia
AU - Carriero, Alessandro
AU - Guglielmo, Marco
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. To date, clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. Standardized protocols for both S-CMR and CTP usually imply the administration of vasodilator agents to induce hyperemia and contrast agents to depict perfusion defects. However, both methods have their own limitations, meaning that optimizing their performance still requires a patient-tailored approach. This review focuses on the characteristics, drawbacks, and future perspectives of these two techniques.
AB - Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. To date, clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. Standardized protocols for both S-CMR and CTP usually imply the administration of vasodilator agents to induce hyperemia and contrast agents to depict perfusion defects. However, both methods have their own limitations, meaning that optimizing their performance still requires a patient-tailored approach. This review focuses on the characteristics, drawbacks, and future perspectives of these two techniques.
KW - cardiac computed tomography perfusion
KW - cardiac coronary syndrome
KW - coronary artery disease
KW - stress imaging
KW - stress magnetic cardiac resonance
UR - http://www.scopus.com/inward/record.url?scp=85161391316&partnerID=8YFLogxK
U2 - 10.3390/jcm12113793
DO - 10.3390/jcm12113793
M3 - Review article
AN - SCOPUS:85161391316
SN - 2077-0383
VL - 12
JO - Journal of Clinical medicine
JF - Journal of Clinical medicine
IS - 11
M1 - 3793
ER -