The next step toward GMP-grade production of engineered immune cells

Guido J J Kierkels; Trudy Straetemans; Moniek A de Witte; Jürgen Kuball

doi:10.1080/2162402X.2015.1076608

The next step toward GMP-grade production of engineered immune cells

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Removing less potent T cell subsets as well as poorly- or non-engineered cells can optimize effectiveness of engineered T cell therapy against cancer. We have recently described a novel, GMP-ready method for the purification of engineered immune cells that might further boost the clinical success of cancer immunotherapy.

Original language	English
Article number	e1076608
Journal	OncoImmunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1080/2162402X.2015.1076608
Publication status	Published - Feb 2016

Keywords

Adoptive immunotherapy
allogeneic stem cell transplantation
GMP grade production
T cell subsets

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10.1080/2162402X.2015.1076608

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title = "The next step toward GMP-grade production of engineered immune cells",

abstract = "Removing less potent T cell subsets as well as poorly- or non-engineered cells can optimize effectiveness of engineered T cell therapy against cancer. We have recently described a novel, GMP-ready method for the purification of engineered immune cells that might further boost the clinical success of cancer immunotherapy.",

keywords = "Adoptive immunotherapy, allogeneic stem cell transplantation, GMP grade production, T cell subsets",

author = "Kierkels, \{Guido J J\} and Trudy Straetemans and \{de Witte\}, \{Moniek A\} and J{\"u}rgen Kuball",

year = "2016",

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AU - Straetemans, Trudy

AU - de Witte, Moniek A

AU - Kuball, Jürgen

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AB - Removing less potent T cell subsets as well as poorly- or non-engineered cells can optimize effectiveness of engineered T cell therapy against cancer. We have recently described a novel, GMP-ready method for the purification of engineered immune cells that might further boost the clinical success of cancer immunotherapy.

KW - Adoptive immunotherapy

KW - allogeneic stem cell transplantation

KW - GMP grade production

KW - T cell subsets

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DO - 10.1080/2162402X.2015.1076608

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JO - OncoImmunology

JF - OncoImmunology

IS - 2

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ER -

The next step toward GMP-grade production of engineered immune cells

Abstract

Keywords

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