TY - JOUR
T1 - The Neutrophil Life Cycle
AU - Hidalgo, Andrés
AU - Chilvers, Edwin R
AU - Summers, Charlotte
AU - Koenderman, Leo
N1 - Funding Information:
The work in the authors laboratories is funded by (ERC) Medical Research Council , Wellcome Trust , GlaxoSmithKline, MedImmune, the NIHR Cambridge Biomedical Research Centre, British Heart Foundation , National Institute for Health, Cambridge NIHR Biomedical Research Centre, the MCIU ( Ministerio de Ciencia, Innovación y Universidades ), the Pro-CNIC Foundation, the Dutch Science Agenda (NWA) and the Netherlands Organization for Scientific Research (NWO). The CNIC is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505).
Funding Information:
The work in the authors laboratories is funded by (ERC) Medical Research Council, Wellcome Trust, GlaxoSmithKline, MedImmune, the NIHR Cambridge Biomedical Research Centre, British Heart Foundation, National Institute for Health, Cambridge NIHR Biomedical Research Centre, the MCIU (Ministerio de Ciencia, Innovaci?n y Universidades), the Pro-CNIC Foundation, the Dutch Science Agenda (NWA) and the Netherlands Organization for Scientific Research (NWO). The CNIC is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505).
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Neutrophils are recognized as an essential part of the innate immune response, but an active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the bone marrow through progenitor intermediaries before entering the blood, in a process that gauges the extramedullary pool size. Once believed to be directly eliminated in the marrow, liver, and spleen, neutrophils, after circulating for less than 1 day, are now known to redistribute into multiple tissues with poorly understood kinetics. In this review, we provide an update on the dynamic distribution of neutrophils across tissues in health and disease, and emphasize differences between humans and model organisms. We further highlight issues to be addressed to exploit the unique features of neutrophils in the clinic.
AB - Neutrophils are recognized as an essential part of the innate immune response, but an active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the bone marrow through progenitor intermediaries before entering the blood, in a process that gauges the extramedullary pool size. Once believed to be directly eliminated in the marrow, liver, and spleen, neutrophils, after circulating for less than 1 day, are now known to redistribute into multiple tissues with poorly understood kinetics. In this review, we provide an update on the dynamic distribution of neutrophils across tissues in health and disease, and emphasize differences between humans and model organisms. We further highlight issues to be addressed to exploit the unique features of neutrophils in the clinic.
UR - http://www.scopus.com/inward/record.url?scp=85066283576&partnerID=8YFLogxK
U2 - 10.1016/j.it.2019.04.013
DO - 10.1016/j.it.2019.04.013
M3 - Review article
C2 - 31153737
SN - 1471-4906
VL - 40
SP - 584
EP - 597
JO - Trends in immunology
JF - Trends in immunology
IS - 7
ER -