The neuro-immune axis: Prospect for novel treatments for mental disorders

Aletta D. Kraneveld; Caroline G.M. de Theije; Floor van Heesch; Yuliya Borre; Sander de Kivit; Berend Olivier; Mechiel Korte; Johan Garssen

doi:10.1111/bcpt.12154

The neuro-immune axis: Prospect for novel treatments for mental disorders

Aletta D. Kraneveld^*, Caroline G.M. de Theije, Floor van Heesch, Yuliya Borre, Sander de Kivit, Berend Olivier, Mechiel Korte, Johan Garssen

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the management of these and possibly other multi-factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach.

Original language	English
Pages (from-to)	128-136
Number of pages	9
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	114
Issue number	1
DOIs	https://doi.org/10.1111/bcpt.12154
Publication status	Published - Jan 2014
Externally published	Yes

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title = "The neuro-immune axis: Prospect for novel treatments for mental disorders",

abstract = "Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the management of these and possibly other multi-factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach.",

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AU - Kraneveld, Aletta D.

AU - de Theije, Caroline G.M.

AU - van Heesch, Floor

AU - Borre, Yuliya

AU - de Kivit, Sander

AU - Olivier, Berend

AU - Korte, Mechiel

AU - Garssen, Johan

PY - 2014/1

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N2 - Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the management of these and possibly other multi-factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach.

AB - Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the management of these and possibly other multi-factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach.

UR - https://www.scopus.com/pages/publications/84890863959

U2 - 10.1111/bcpt.12154

DO - 10.1111/bcpt.12154

M3 - Review article

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JO - Basic and Clinical Pharmacology and Toxicology

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IS - 1

ER -

The neuro-immune axis: Prospect for novel treatments for mental disorders

Abstract

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