The Neonatal Connectome During Preterm Brain Development

Martijn P van den Heuvel; Karina J Kersbergen; Marcel A de Reus; Kristin Keunen; René S Kahn; Floris Groenendaal; Linda S de Vries; Manon J N L Benders

doi:10.1093/cercor/bhu095

The Neonatal Connectome During Preterm Brain Development

Martijn P van den Heuvel, Karina J Kersbergen, Marcel A de Reus, Kristin Keunen, René S Kahn, Floris Groenendaal, Linda S de Vries, Manon J N L Benders

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The human connectome is the result of an elaborate developmental trajectory. Acquiring diffusion-weighted imaging and resting-state fMRI, we studied connectome formation during the preterm phase of macroscopic connectome genesis. In total, 27 neonates were scanned at week 30 and/or week 40 gestational age (GA). Examining the architecture of the neonatal anatomical brain network revealed a clear presence of a small-world modular organization before term birth. Analysis of neonatal functional connectivity (FC) showed the early formation of resting-state networks, suggesting that functional networks are present in the preterm brain, albeit being in an immature state. Moreover, structural and FC patterns of the neonatal brain network showed strong overlap with connectome architecture of the adult brain (85 and 81%, respectively). Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P

Original language	English
Pages (from-to)	3000-3013
Number of pages	14
Journal	Cerebral Cortex
Volume	25
Issue number	9
DOIs	https://doi.org/10.1093/cercor/bhu095 https://doi.org/10.1093/cercor/bhu095
Publication status	Published - Sept 2015

Keywords

connectome
development
functional connectivity
neonatal
structural connectivity
RICH-CLUB ORGANIZATION
HUMAN CEREBRAL-CORTEX
RESTING-STATE NETWORKS
INTRINSIC FUNCTIONAL CONNECTIVITY
GRAPH-THEORETICAL ANALYSIS
WHITE-MATTER DEVELOPMENT
DEVELOPING RHESUS-MONKEY
STRUCTURAL CONNECTIVITY
CORTICAL NETWORKS
SMALL-WORLD

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title = "The Neonatal Connectome During Preterm Brain Development",

abstract = "The human connectome is the result of an elaborate developmental trajectory. Acquiring diffusion-weighted imaging and resting-state fMRI, we studied connectome formation during the preterm phase of macroscopic connectome genesis. In total, 27 neonates were scanned at week 30 and/or week 40 gestational age (GA). Examining the architecture of the neonatal anatomical brain network revealed a clear presence of a small-world modular organization before term birth. Analysis of neonatal functional connectivity (FC) showed the early formation of resting-state networks, suggesting that functional networks are present in the preterm brain, albeit being in an immature state. Moreover, structural and FC patterns of the neonatal brain network showed strong overlap with connectome architecture of the adult brain (85 and 81%, respectively). Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P",

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AU - van den Heuvel, Martijn P

AU - Kersbergen, Karina J

AU - de Reus, Marcel A

AU - Keunen, Kristin

AU - Kahn, René S

AU - Groenendaal, Floris

AU - de Vries, Linda S

AU - Benders, Manon J N L

N1 - © The Author 2014. Published by Oxford University Press.

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JO - Cerebral Cortex

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The Neonatal Connectome During Preterm Brain Development

Abstract

Keywords

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