The murine Hox-2.4 promoter contains a functional octamer motif

Fried Zwartkruis; Truus Hoeijmakers; Jacqueline Deschamps; Frits Meijlink

doi:10.1093/nar/20.7.1599

The murine Hox-2.4 promoter contains a functional octamer motif

Fried Zwartkruis, Truus Hoeijmakers, Jacqueline Deschamps, Frits Meijlink^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenlc potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors Influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.

Original language	English
Pages (from-to)	1599-1606
Number of pages	8
Journal	Nucleic acids research
Volume	20
Issue number	7
DOIs	https://doi.org/10.1093/nar/20.7.1599
Publication status	Published - 11 Apr 1992
Externally published	Yes

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abstract = "Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenlc potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors Influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.",

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AU - Zwartkruis, Fried

AU - Hoeijmakers, Truus

AU - Deschamps, Jacqueline

AU - Meijlink, Frits

PY - 1992/4/11

Y1 - 1992/4/11

N2 - Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenlc potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors Influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.

AB - Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenlc potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors Influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.

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The murine Hox-2.4 promoter contains a functional octamer motif

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