The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme

Dirk Jan E. Opstelten; Ronald Vogels; Benoît Robert; Eric Kalkhoven; Fried Zwartkruis; Lia de Laaf; Olivier H. Destrée; Jacqueline Deschamps; Kirstie A. Lawson; Frits Meijlink

doi:10.1016/0925-4773(91)90089-O

The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme

Dirk Jan E. Opstelten, Ronald Vogels, Benoît Robert, Eric Kalkhoven, Fried Zwartkruis, Lia de Laaf, Olivier H. Destrée, Jacqueline Deschamps, Kirstie A. Lawson, Frits Meijlink^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The murine S8 gene, originally identified by Kongsuwan et al. [EMBO J. 7(1988)2131–2138] encodes a homeodomain which resembles those of the paired family. We studied the expression pattern during mid-gestation embryogenesis of S8 by in situ hybridization. Expression was detected locally in craniofacial mesenchyme, in the limb, the heart and the somites and sclerotomes all along the axis, and was absent from the central and peripheral nervous system, splanchnopleure, and endodermal derivatives. This pattern differs considerably from that of most previously described homeobox containing genes. By genetic analysis, the gene was located on chromosome 2, about 20 cM from the HOX-4 cluster.

Original language	English
Pages (from-to)	29-41
Number of pages	13
Journal	Mechanisms of Development
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0925-4773(91)90089-O
Publication status	Published - 1991
Externally published	Yes

Keywords

Connective tissue
Homeobox gene
In situ hybridization
Mesenchyme
Mouse chromosome-2

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@article{f0045d872cb6408baa5d32ce6073f17a,

title = "The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme",

abstract = "The murine S8 gene, originally identified by Kongsuwan et al. [EMBO J. 7(1988)2131–2138] encodes a homeodomain which resembles those of the paired family. We studied the expression pattern during mid-gestation embryogenesis of S8 by in situ hybridization. Expression was detected locally in craniofacial mesenchyme, in the limb, the heart and the somites and sclerotomes all along the axis, and was absent from the central and peripheral nervous system, splanchnopleure, and endodermal derivatives. This pattern differs considerably from that of most previously described homeobox containing genes. By genetic analysis, the gene was located on chromosome 2, about 20 cM from the HOX-4 cluster.",

keywords = "Connective tissue, Homeobox gene, In situ hybridization, Mesenchyme, Mouse chromosome-2",

author = "Opstelten, {Dirk Jan E.} and Ronald Vogels and Beno{\^i}t Robert and Eric Kalkhoven and Fried Zwartkruis and Laaf, {Lia de} and Destr{\'e}e, {Olivier H.} and Jacqueline Deschamps and Lawson, {Kirstie A.} and Frits Meijlink",

year = "1991",

doi = "10.1016/0925-4773(91)90089-O",

language = "English",

volume = "34",

pages = "29--41",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier Ireland Ltd",

number = "1",

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T1 - The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme

AU - Opstelten, Dirk Jan E.

AU - Vogels, Ronald

AU - Robert, Benoît

AU - Kalkhoven, Eric

AU - Zwartkruis, Fried

AU - Laaf, Lia de

AU - Destrée, Olivier H.

AU - Deschamps, Jacqueline

AU - Lawson, Kirstie A.

AU - Meijlink, Frits

PY - 1991

Y1 - 1991

N2 - The murine S8 gene, originally identified by Kongsuwan et al. [EMBO J. 7(1988)2131–2138] encodes a homeodomain which resembles those of the paired family. We studied the expression pattern during mid-gestation embryogenesis of S8 by in situ hybridization. Expression was detected locally in craniofacial mesenchyme, in the limb, the heart and the somites and sclerotomes all along the axis, and was absent from the central and peripheral nervous system, splanchnopleure, and endodermal derivatives. This pattern differs considerably from that of most previously described homeobox containing genes. By genetic analysis, the gene was located on chromosome 2, about 20 cM from the HOX-4 cluster.

AB - The murine S8 gene, originally identified by Kongsuwan et al. [EMBO J. 7(1988)2131–2138] encodes a homeodomain which resembles those of the paired family. We studied the expression pattern during mid-gestation embryogenesis of S8 by in situ hybridization. Expression was detected locally in craniofacial mesenchyme, in the limb, the heart and the somites and sclerotomes all along the axis, and was absent from the central and peripheral nervous system, splanchnopleure, and endodermal derivatives. This pattern differs considerably from that of most previously described homeobox containing genes. By genetic analysis, the gene was located on chromosome 2, about 20 cM from the HOX-4 cluster.

KW - Connective tissue

KW - Homeobox gene

KW - In situ hybridization

KW - Mesenchyme

KW - Mouse chromosome-2

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DO - 10.1016/0925-4773(91)90089-O

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SN - 0925-4773

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EP - 41

JO - Mechanisms of Development

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ER -

The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme

Abstract

Keywords

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