The mild stimulation in vitro fertilization protocol

Geeta Nargund; Adrija Kumar Datta; Bart C.J.M. Fauser

doi:10.1016/B978-0-323-85687-4.00027-0

The mild stimulation in vitro fertilization protocol

Geeta Nargund, Adrija Kumar Datta, Bart C.J.M. Fauser

Reproductive Medicine & Gynecology - Medical

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

There is mounting evidence that the proportion of high-grade or euploid embryo cannot be increased by intensifying ovarian stimulation in IVF. Randomised controlled trials failed to demonstrate improvement in the livebirth rates by administering >150 IU daily dose of gonadotropins. There is no convincing evidence of improved cumulative livebirth with higher stimulation dose. IVF success relates to ovarian response, which correlates with woman’s age and ovarian reserve but not with the intensity of stimulation. Mild ovarian stimulation, defined as less than or equal to 150 IU of daily gonadotropin, adjusted with BMI, may result in equivalent level of success whilst reducing the risk of OHSS and other risks associated with over-response. Mild stimulation IVF is the way forward to make IVF safer, woman-friendly and more affordable.

Original language	English
Title of host publication	Handbook of Current and Novel Protocols for the Treatment of Infertility
Editors	M.H. Dahan, H.M. Fatemi, N.P. Polyzos, J.A. Garcia-Velasco
Publisher	Elsevier
Chapter	11
Pages	161-177
Number of pages	17
ISBN (Electronic)	9780323856874
ISBN (Print)	9780323901062
DOIs	https://doi.org/10.1016/B978-0-323-85687-4.00027-0
Publication status	Published - 2023

Keywords

Cumulative pregnancy outcome
Cycle cancellation
Endometrial receptivity
Mild ovarian stimulation
Oocyte competency

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10.1016/B978-0-323-85687-4.00027-0

Cite this

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abstract = "There is mounting evidence that the proportion of high-grade or euploid embryo cannot be increased by intensifying ovarian stimulation in IVF. Randomised controlled trials failed to demonstrate improvement in the livebirth rates by administering >150 IU daily dose of gonadotropins. There is no convincing evidence of improved cumulative livebirth with higher stimulation dose. IVF success relates to ovarian response, which correlates with woman{\textquoteright}s age and ovarian reserve but not with the intensity of stimulation. Mild ovarian stimulation, defined as less than or equal to 150 IU of daily gonadotropin, adjusted with BMI, may result in equivalent level of success whilst reducing the risk of OHSS and other risks associated with over-response. Mild stimulation IVF is the way forward to make IVF safer, woman-friendly and more affordable.",

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author = "Geeta Nargund and Datta, {Adrija Kumar} and Fauser, {Bart C.J.M.}",

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The mild stimulation in vitro fertilization protocol. / Nargund, Geeta; Datta, Adrija Kumar; Fauser, Bart C.J.M.
Handbook of Current and Novel Protocols for the Treatment of Infertility. ed. / M.H. Dahan; H.M. Fatemi; N.P. Polyzos; J.A. Garcia-Velasco. Elsevier, 2023. p. 161-177.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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The mild stimulation in vitro fertilization protocol

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Keywords

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