@article{54b4d1c731f04d749e5b773851cdbc96,
title = "The lung is a host defense niche for immediate neutrophil-mediated vascular protection",
abstract = "Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid treatment. However, up-regulation of host defense proteins through Toll-like receptors (TLRs) and nuclear factor B requires hours after endotoxin detection. Using confocal pulmonary intravital microscopy, we identified that the lung provides a TLR4{\textendash}Myd88 (myeloid differentiation primary response gene 88){\textendash}dependent and abl tyrosine kinase{\textendash}dependent niche for immediate CD11b-dependent neutrophil responses to endotoxin and Gram-negative bloodstream pathogens. In an in vivo model of bacteremia, neutrophils crawled to and rapidly phagocytosed Escherichia coli sequestered to the lung endothelium. Therefore, the lung capillaries provide a vascular defensive niche whereby endothelium and neutrophils cooperate for immediate detection and capture of disseminating pathogens.",
author = "Yipp, \{Bryan G.\} and Kim, \{Jung Hwan\} and Ronald Lima and Zbytnuik, \{Lori D.\} and Bjӧrn Petri and Nick Swanlund and May Ho and Szeto, \{Vivian G.\} and Tamar Tak and Leo Koenderman and Peter Pickkers and Tool, \{Anton T.J.\} and Kuijpers, \{Taco W.\} and \{van den Berg\}, \{Timo K.\} and Looney, \{Mark R.\} and Krummel, \{Matthew F.\} and Paul Kubes",
note = "Funding Information: We thank the Mouse Phenomics Resources Laboratory, funded by the Snyder Institute, and the Flow Cytometry Core Facility at the University of Calgary. This study was supported by operating grants from the Canadian Institutes of Health Research (CIHR) (RS-342013) and the Department of Critical Care Medicine at the University of Calgary and by bridge funding from the University of Calgary Medical Group to B.G.Y. Infrastructure funding was provided by the Canada Foundation for Innovation John R. Evans Leaders fund with matching support from the Alberta Enterprise and Advanced Education Research Capacity Program. B.G.Y. is a tier II Canada Research Chair in Pulmonary Immunology, Inflammation and Host Defence. P.K. was supported by the CIHR Team Grant: Health Challenges in Chronic Inflammation Initiative. P.K. is a tier I Canada Research Chair Leukocyte Recruitment in inflammatory disease. L.K. was supported by a grant from the Dutch Lung Foundation (3.2.10.052). Publisher Copyright: 2017 {\textcopyright} The Authors.",
year = "2017",
month = apr,
day = "28",
doi = "10.1126/sciimmunol.aam8929",
language = "English",
volume = "2",
journal = "Science Immunology",
publisher = "American Association for the Advancement of Science",
number = "10",
}