The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

D.I. Swerdlow; M.V. Holmes; K.B. Kuchenbaecker; J.E.L. Engmann; T. Shah; R. Sofat; Y. Guo; C. Chung; A. Peasey; R. Pfister; S.P. Mooijaart; H.A. Ireland; M. Leusink; C. Langenberg; K.W. Li; J. Palmen; P. Howard; J.A. Cooper; F. Drenos; J. Hardy; M.A. Nalls; Y.R. Li; G. Lowe; M. Stewart; S.J. Bielinski; J. Peto; N.J. Timpson; J. Gallacher; M. Dunlop; R. Houlston; I. Tomlinson; I. Tzoulaki; J. Luan; J.M.A. Boer; N.G. Forouhi; N.C. Onland-Moret; Y.T. van der Schouw; R.B. Schnabel; J.A. Hubacek; R. Kubinova; M. Baceviciene; A. Tamosiunas; A. Pajak; R. Topor-Madry; S. Malyutina; D. Baldassarre; B. Sennblad; E. Tremoli; J.F. Meschia; A. Singleton; G. Navis; I.M. Leach; S.J.L. Bakker; R.T. Gansevoort; I. Ford; S.E. Epstein; M.S. Burnett; J.M. Devany; J.W. Jukema; R.G.J. Westendorp; G.J. de Borst; Y. van der Graaf; P.A. de Jong; A.H. Maitland-van der Zee; O.H. Klungel; A. de Boer; P.A. Doevendans; J.W. Stephens; C.B. Eaton; J.G. Robinson; J.E. Manson; F. Gerry; R. Fowkes; R.M. Frayling; J.F. Price; P.H. Whincup; R.W. Morris; D.A. Lawlor; G.D. Smith; Y.B. Shlomo; S. Redline; L.A. Lange; M. Kumari; N.J. Wareham; W.M.M. Verschuren; E.J. Benjamin; J.C. Whittaker; A. Hamsten; F. Dudbridge; J.A.C. Delaney; A. Wong; D. Kuh; R. Hardy; B. Almoguera Castillo; J.J. Connolly; P. van der Harst; E.J. Brunner; M.G. Marmot; C.L. Wassel; S.E. Humphries; P.J. Talmud; M. Kivimaki; F.W. Asselbergs; M. Voevoda; M. Bobak; H. Pikhart; J.G. Wilson; H. Hakonarson; A. Reiner; B.J. Keating; N. Sattar; A.D. Hingorani; J.P. Casas

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

D.I. Swerdlow
, M.V. Holmes
, K.B. Kuchenbaecker
, J.E.L. Engmann
, T. Shah
, R. Sofat
, Y. Guo
, C. Chung
, A. Peasey
, R. Pfister
, S.P. Mooijaart
, H.A. Ireland
, M. Leusink
, C. Langenberg
, K.W. Li
, J. Palmen
, P. Howard
, J.A. Cooper
, F. Drenos
, J. Hardy

M.A. Nalls, Y.R. Li, G. Lowe, M. Stewart, S.J. Bielinski, J. Peto, N.J. Timpson, J. Gallacher, M. Dunlop, R. Houlston, I. Tomlinson, I. Tzoulaki, J. Luan, J.M.A. Boer, N.G. Forouhi, N.C. Onland-Moret, Y.T. van der Schouw, R.B. Schnabel, J.A. Hubacek, R. Kubinova, M. Baceviciene, A. Tamosiunas, A. Pajak, R. Topor-Madry, S. Malyutina, D. Baldassarre, B. Sennblad, E. Tremoli, J.F. Meschia, A. Singleton, G. Navis, I.M. Leach, S.J.L. Bakker, R.T. Gansevoort, I. Ford, S.E. Epstein, M.S. Burnett, J.M. Devany, J.W. Jukema, R.G.J. Westendorp, G.J. de Borst, Y. van der Graaf, P.A. de Jong, A.H. Maitland-van der Zee, O.H. Klungel, A. de Boer, P.A. Doevendans, J.W. Stephens, C.B. Eaton, J.G. Robinson, J.E. Manson, F. Gerry, R. Fowkes, R.M. Frayling, J.F. Price, P.H. Whincup, R.W. Morris, D.A. Lawlor, G.D. Smith, Y.B. Shlomo, S. Redline, L.A. Lange, M. Kumari, N.J. Wareham, W.M.M. Verschuren, E.J. Benjamin, J.C. Whittaker, A. Hamsten, F. Dudbridge, J.A.C. Delaney, A. Wong, D. Kuh, R. Hardy, B. Almoguera Castillo, J.J. Connolly, P. van der Harst, E.J. Brunner, M.G. Marmot, C.L. Wassel, S.E. Humphries, P.J. Talmud, M. Kivimaki, F.W. Asselbergs, M. Voevoda, M. Bobak, H. Pikhart, J.G. Wilson, H. Hakonarson, A. Reiner, B.J. Keating, N. Sattar, A.D. Hingorani, J.P. Casas

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1214-1224
Number of pages	11
Journal	The Lancet
Volume	379
Issue number	9822
Publication status	Published - 2012

Access to Document

http://www.ncbi.nlm.nih.gov/pubmed/22421340

Cite this

Swerdlow, D. I., Holmes, M. V., Kuchenbaecker, K. B., Engmann, J. E. L., Shah, T., Sofat, R., Guo, Y., Chung, C., Peasey, A., Pfister, R., Mooijaart, S. P., Ireland, H. A., Leusink, M., Langenberg, C., Li, K. W., Palmen, J., Howard, P., Cooper, J. A., Drenos, F., ... Casas, J. P. (2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. The Lancet, 379(9822), 1214-1224. http://www.ncbi.nlm.nih.gov/pubmed/22421340

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year = "2012",

language = "English",

volume = "379",

pages = "1214--1224",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier",

number = "9822",

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Swerdlow, DI, Holmes, MV, Kuchenbaecker, KB, Engmann, JEL, Shah, T, Sofat, R, Guo, Y, Chung, C, Peasey, A, Pfister, R, Mooijaart, SP, Ireland, HA, Leusink, M, Langenberg, C, Li, KW, Palmen, J, Howard, P, Cooper, JA, Drenos, F, Hardy, J, Nalls, MA, Li, YR, Lowe, G, Stewart, M, Bielinski, SJ, Peto, J, Timpson, NJ, Gallacher, J, Dunlop, M, Houlston, R, Tomlinson, I, Tzoulaki, I, Luan, J, Boer, JMA, Forouhi, NG, Onland-Moret, NC , van der Schouw, YT, Schnabel, RB, Hubacek, JA, Kubinova, R, Baceviciene, M, Tamosiunas, A, Pajak, A, Topor-Madry, R, Malyutina, S, Baldassarre, D, Sennblad, B, Tremoli, E, Meschia, JF, Singleton, A, Navis, G, Leach, IM, Bakker, SJL, Gansevoort, RT, Ford, I, Epstein, SE, Burnett, MS, Devany, JM, Jukema, JW, Westendorp, RGJ, de Borst, GJ , van der Graaf, Y , de Jong, PA, Maitland-van der Zee, AH, Klungel, OH, de Boer, A, Doevendans, PA, Stephens, JW, Eaton, CB, Robinson, JG, Manson, JE, Gerry, F, Fowkes, R, Frayling, RM, Price, JF, Whincup, PH, Morris, RW, Lawlor, DA, Smith, GD, Shlomo, YB, Redline, S, Lange, LA, Kumari, M, Wareham, NJ, Verschuren, WMM, Benjamin, EJ, Whittaker, JC, Hamsten, A, Dudbridge, F, Delaney, JAC, Wong, A, Kuh, D, Hardy, R, Almoguera Castillo, B, Connolly, JJ, van der Harst, P, Brunner, EJ, Marmot, MG, Wassel, CL, Humphries, SE, Talmud, PJ, Kivimaki, M, Asselbergs, FW, Voevoda, M, Bobak, M, Pikhart, H, Wilson, JG, Hakonarson, H, Reiner, A, Keating, BJ, Sattar, N, Hingorani, AD & Casas, JP 2012, 'The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis', The Lancet, vol. 379, no. 9822, pp. 1214-1224. <http://www.ncbi.nlm.nih.gov/pubmed/22421340>

TY - JOUR

T1 - The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

AU - Swerdlow, D.I.

AU - Holmes, M.V.

AU - Kuchenbaecker, K.B.

AU - Engmann, J.E.L.

AU - Shah, T.

AU - Sofat, R.

AU - Guo, Y.

AU - Chung, C.

AU - Peasey, A.

AU - Pfister, R.

AU - Mooijaart, S.P.

AU - Ireland, H.A.

AU - Leusink, M.

AU - Langenberg, C.

AU - Li, K.W.

AU - Palmen, J.

AU - Howard, P.

AU - Cooper, J.A.

AU - Drenos, F.

AU - Hardy, J.

AU - Nalls, M.A.

AU - Li, Y.R.

AU - Lowe, G.

AU - Stewart, M.

AU - Bielinski, S.J.

AU - Peto, J.

AU - Timpson, N.J.

AU - Gallacher, J.

AU - Dunlop, M.

AU - Houlston, R.

AU - Tomlinson, I.

AU - Tzoulaki, I.

AU - Luan, J.

AU - Boer, J.M.A.

AU - Forouhi, N.G.

AU - Onland-Moret, N.C.

AU - van der Schouw, Y.T.

AU - Schnabel, R.B.

AU - Hubacek, J.A.

AU - Kubinova, R.

AU - Baceviciene, M.

AU - Tamosiunas, A.

AU - Pajak, A.

AU - Topor-Madry, R.

AU - Malyutina, S.

AU - Baldassarre, D.

AU - Sennblad, B.

AU - Tremoli, E.

AU - Meschia, J.F.

AU - Singleton, A.

AU - Navis, G.

AU - Leach, I.M.

AU - Bakker, S.J.L.

AU - Gansevoort, R.T.

AU - Ford, I.

AU - Epstein, S.E.

AU - Burnett, M.S.

AU - Devany, J.M.

AU - Jukema, J.W.

AU - Westendorp, R.G.J.

AU - de Borst, G.J.

AU - van der Graaf, Y.

AU - de Jong, P.A.

AU - Maitland-van der Zee, A.H.

AU - Klungel, O.H.

AU - de Boer, A.

AU - Doevendans, P.A.

AU - Stephens, J.W.

AU - Eaton, C.B.

AU - Robinson, J.G.

AU - Manson, J.E.

AU - Gerry, F.

AU - Fowkes, R.

AU - Frayling, R.M.

AU - Price, J.F.

AU - Whincup, P.H.

AU - Morris, R.W.

AU - Lawlor, D.A.

AU - Smith, G.D.

AU - Shlomo, Y.B.

AU - Redline, S.

AU - Lange, L.A.

AU - Kumari, M.

AU - Wareham, N.J.

AU - Verschuren, W.M.M.

AU - Benjamin, E.J.

AU - Whittaker, J.C.

AU - Hamsten, A.

AU - Dudbridge, F.

AU - Delaney, J.A.C.

AU - Wong, A.

AU - Kuh, D.

AU - Hardy, R.

AU - Almoguera Castillo, B.

AU - Connolly, J.J.

AU - van der Harst, P.

AU - Brunner, E.J.

AU - Marmot, M.G.

AU - Wassel, C.L.

AU - Humphries, S.E.

AU - Talmud, P.J.

AU - Kivimaki, M.

AU - Asselbergs, F.W.

AU - Voevoda, M.

AU - Bobak, M.

AU - Pikhart, H.

AU - Wilson, J.G.

AU - Hakonarson, H.

AU - Reiner, A.

AU - Keating, B.J.

AU - Sattar, N.

AU - Hingorani, A.D.

AU - Casas, J.P.

PY - 2012

Y1 - 2012

M3 - Article

SN - 0140-6736

VL - 379

SP - 1214

EP - 1224

JO - The Lancet

JF - The Lancet

IS - 9822

ER -