The influence of PCP prophylaxis on bacteriuria. Incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients

D. A. Van Dooyeweert; M. M.E. Schneider; J. C.C. Borleffs; A. I.M. Hoepelman

doi:10.1016/S0300-2977(96)00061-7

The influence of PCP prophylaxis on bacteriuria. Incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients

D. A. Van Dooyeweert
, M. M.E. Schneider
, J. C.C. Borleffs
, A. I.M. Hoepelman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Background: Earlier studies have shown that men infected with HIV-1 and a CD4+ cell count below 200 mm³ are at increased risk for bacteriuria. We studied the effect of 3 Pneumocystis carinii (PCP) prophylaxis regimens (low-dose TMP/SMZ, high-dose TMP/SMZ and pentamidine aerosol) on the incidence of bacteriuria and resistance development to TMP/SMZ. Methods: Retrospective analysis of 103 HIV-positive patients. Results: Nine patients using pentamidine had a positive culture (32%), compared to 9 patients using low-dose TMP/SMZ (17%) and 5 patients using high-dose TMP/SMZ (22%). These differences were not significant (P = 0.207). However, almost all episodes in patients using TMP/SMZ were due to infection with a resistant strain. Conclusion: PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance.

Original language	English
Pages (from-to)	225-227
Number of pages	3
Journal	Netherlands Journal of Medicine
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/S0300-2977(96)00061-7
Publication status	Published - 9 Dec 1996

Keywords

PCP prophylaxis
TMP/SMX resistance
Urinary tract infection

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10.1016/S0300-2977(96)00061-7

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title = "The influence of PCP prophylaxis on bacteriuria. Incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients",

abstract = "Background: Earlier studies have shown that men infected with HIV-1 and a CD4+ cell count below 200 mm3 are at increased risk for bacteriuria. We studied the effect of 3 Pneumocystis carinii (PCP) prophylaxis regimens (low-dose TMP/SMZ, high-dose TMP/SMZ and pentamidine aerosol) on the incidence of bacteriuria and resistance development to TMP/SMZ. Methods: Retrospective analysis of 103 HIV-positive patients. Results: Nine patients using pentamidine had a positive culture (32\%), compared to 9 patients using low-dose TMP/SMZ (17\%) and 5 patients using high-dose TMP/SMZ (22\%). These differences were not significant (P = 0.207). However, almost all episodes in patients using TMP/SMZ were due to infection with a resistant strain. Conclusion: PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance.",

keywords = "PCP prophylaxis, TMP/SMX resistance, Urinary tract infection",

author = "\{Van Dooyeweert\}, \{D. A.\} and Schneider, \{M. M.E.\} and Borleffs, \{J. C.C.\} and Hoepelman, \{A. I.M.\}",

year = "1996",

month = dec,

day = "9",

doi = "10.1016/S0300-2977(96)00061-7",

language = "English",

volume = "49",

pages = "225--227",

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The influence of PCP prophylaxis on bacteriuria. Incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients. / Van Dooyeweert, D. A.; Schneider, M. M.E.; Borleffs, J. C.C. et al.
In: Netherlands Journal of Medicine, Vol. 49, No. 6, 09.12.1996, p. 225-227.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The influence of PCP prophylaxis on bacteriuria. Incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients

AU - Van Dooyeweert, D. A.

AU - Schneider, M. M.E.

AU - Borleffs, J. C.C.

AU - Hoepelman, A. I.M.

PY - 1996/12/9

Y1 - 1996/12/9

N2 - Background: Earlier studies have shown that men infected with HIV-1 and a CD4+ cell count below 200 mm3 are at increased risk for bacteriuria. We studied the effect of 3 Pneumocystis carinii (PCP) prophylaxis regimens (low-dose TMP/SMZ, high-dose TMP/SMZ and pentamidine aerosol) on the incidence of bacteriuria and resistance development to TMP/SMZ. Methods: Retrospective analysis of 103 HIV-positive patients. Results: Nine patients using pentamidine had a positive culture (32%), compared to 9 patients using low-dose TMP/SMZ (17%) and 5 patients using high-dose TMP/SMZ (22%). These differences were not significant (P = 0.207). However, almost all episodes in patients using TMP/SMZ were due to infection with a resistant strain. Conclusion: PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance.

AB - Background: Earlier studies have shown that men infected with HIV-1 and a CD4+ cell count below 200 mm3 are at increased risk for bacteriuria. We studied the effect of 3 Pneumocystis carinii (PCP) prophylaxis regimens (low-dose TMP/SMZ, high-dose TMP/SMZ and pentamidine aerosol) on the incidence of bacteriuria and resistance development to TMP/SMZ. Methods: Retrospective analysis of 103 HIV-positive patients. Results: Nine patients using pentamidine had a positive culture (32%), compared to 9 patients using low-dose TMP/SMZ (17%) and 5 patients using high-dose TMP/SMZ (22%). These differences were not significant (P = 0.207). However, almost all episodes in patients using TMP/SMZ were due to infection with a resistant strain. Conclusion: PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance.

KW - PCP prophylaxis

KW - TMP/SMX resistance

KW - Urinary tract infection

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M3 - Article

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AN - SCOPUS:0029974066

SN - 0300-2977

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JF - Netherlands Journal of Medicine

IS - 6

ER -

The influence of PCP prophylaxis on bacteriuria. Incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients

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