The influence of body mass index on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in women with early-stage breast cancer

Lishi Lin, Marcel Soesan, Dorieke E M van Balen, Jos H Beijnen, Alwin D R Huitema

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Abstract

Purpose: To investigate the influence of body mass index (BMI) on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in early breast cancer patients. Methods: Early-stage breast cancer patients who received (neo)adjuvant weekly paclitaxel 80 mg/m 2 chemotherapy were included in this retrospective study. Patients were divided into three groups based on their BMI: lean, overweight, and obese. Logistic regression was used to assess for association between BMI with administered relative dose intensity (RDI) < 85%. The occurrence of treatment modifications and the pathological response on neoadjuvant chemotherapy were compared between BMI categories. Results: Four hundred (400) patients were included in this study; 200 (50%) lean, 125 (31%) overweight, and 75 (19%) obese patients. The adjusted odds ratio to receive RDI < 85% for BMI was 1.02 (p value,.263). Treatment modifications occurred in 115 (58%), 82 (66%), and 52 (69%) patients in the respective BMI categories (p value =.132). Peripheral neuropathy was observed in 79 (40%), 58 (46%), and 41 (55%) patients in the lean, overweight, and obese group (p value =.069), whereas hematologic toxicity was observed in 31 (16%), 10 (8%), and 4 (5%) patients (p value =.025). Pathological complete response was observed in 22 (17%), 11 (14%), and 6 (13%) patients in the respective BMI categories (p value =.799). Conclusion: BMI did not significantly influence the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy. Therefore, the results of this study align with current guideline recommendations of using full-weight-based paclitaxel chemotherapy in obese patients.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalBreast Cancer Research and Treatment
Volume195
Issue number3
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Body mass index
  • Breast cancer
  • Chemotherapy
  • Obesity
  • Paclitaxel
  • Relative dose intensity

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