The influence of amphetamine on language activation: An fMRI study

I.E.C. Sommer; B. Oranje; N.F. Ramsey; FA Klerk; R.C.W. Mandl; H.G.M. Westenberg; R.S. Kahn

doi:10.1007/s00213-005-0176-3

The influence of amphetamine on language activation: An fMRI study

I.E.C. Sommer, B. Oranje, N.F. Ramsey, FA Klerk, R.C.W. Mandl, H.G.M. Westenberg, R.S. Kahn

Psychiatry

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Rationale: Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language. Methods: To test this hypothesis, language activation was measured twice with functional magnetic resonance imaging in ten healthy right-handed men in a double-blind crossover design 2 h after amphetamine or placebo administration. Results: Language-related activation increased significantly in task-related areas, but the individual lateralization index was not affected in the amphetamine condition as compared to placebo. Conclusions: This finding suggests that short-termed alterations in the dopaminergic neurotransmission do not affect language dominance.

Original language	English
Pages (from-to)	387-393
Number of pages	7
Journal	Psychopharmacology
Volume	183
Issue number	4
DOIs	https://doi.org/10.1007/s00213-005-0176-3
Publication status	Published - 1 Jan 2006

Keywords

Amphetamine
Cerebral dominance
Dopamine
fMRI
Language lateralization

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abstract = "Rationale: Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language. Methods: To test this hypothesis, language activation was measured twice with functional magnetic resonance imaging in ten healthy right-handed men in a double-blind crossover design 2 h after amphetamine or placebo administration. Results: Language-related activation increased significantly in task-related areas, but the individual lateralization index was not affected in the amphetamine condition as compared to placebo. Conclusions: This finding suggests that short-termed alterations in the dopaminergic neurotransmission do not affect language dominance.",

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T2 - An fMRI study

AU - Sommer, I.E.C.

AU - Oranje, B.

AU - Ramsey, N.F.

AU - Klerk, FA

AU - Mandl, R.C.W.

AU - Westenberg, H.G.M.

AU - Kahn, R.S.

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AB - Rationale: Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language. Methods: To test this hypothesis, language activation was measured twice with functional magnetic resonance imaging in ten healthy right-handed men in a double-blind crossover design 2 h after amphetamine or placebo administration. Results: Language-related activation increased significantly in task-related areas, but the individual lateralization index was not affected in the amphetamine condition as compared to placebo. Conclusions: This finding suggests that short-termed alterations in the dopaminergic neurotransmission do not affect language dominance.

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The influence of amphetamine on language activation: An fMRI study

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Keywords

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