The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis

Kristiana Salmon; Matthew C Kiernan; Seung H Kim; Peter M Andersen; Adriano Chio; Leonard H van den Berg; Philip Van Damme; Ammar Al-Chalabi; Patricia Lillo; Jinsy A Andrews; Angela Genge

doi:10.1093/brain/awab472

The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis

Kristiana Salmon, Matthew C Kiernan, Seung H Kim, Peter M Andersen, Adriano Chio, Leonard H van den Berg, Philip Van Damme, Ammar Al-Chalabi, Patricia Lillo, Jinsy A Andrews, Angela Genge

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Several genetically-targeted therapies are being developed for ALS. Research is increasingly supportive of a greater incidence of clinically actionable variants in sporadic ALS than previously reported. Salmon et al. outline the need to improve access, and offer genetic testing to all people diagnosed with ALS.

Original language	English
Pages (from-to)	1207-1210
Number of pages	4
Journal	Brain : a journal of neurology
Volume	145
Issue number	4
Early online date	10 Jan 2022
DOIs	https://doi.org/10.1093/brain/awab472
Publication status	Published - 24 May 2022

Keywords

Amyotrophic Lateral Sclerosis/diagnosis
Genetic Testing
Humans
Mutation/genetics

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10.1093/brain/awab472Licence: CC BY-NC

awab472Final published version, 583 KBLicence: CC BY-NC

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title = "The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis",

abstract = "Several genetically-targeted therapies are being developed for ALS. Research is increasingly supportive of a greater incidence of clinically actionable variants in sporadic ALS than previously reported. Salmon et al. outline the need to improve access, and offer genetic testing to all people diagnosed with ALS.",

keywords = "Amyotrophic Lateral Sclerosis/diagnosis, Genetic Testing, Humans, Mutation/genetics",

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AU - Salmon, Kristiana

AU - Kiernan, Matthew C

AU - Kim, Seung H

AU - Andersen, Peter M

AU - Chio, Adriano

AU - van den Berg, Leonard H

AU - Van Damme, Philip

AU - Al-Chalabi, Ammar

AU - Lillo, Patricia

AU - Andrews, Jinsy A

AU - Genge, Angela

PY - 2022/5/24

Y1 - 2022/5/24

N2 - Several genetically-targeted therapies are being developed for ALS. Research is increasingly supportive of a greater incidence of clinically actionable variants in sporadic ALS than previously reported. Salmon et al. outline the need to improve access, and offer genetic testing to all people diagnosed with ALS.

AB - Several genetically-targeted therapies are being developed for ALS. Research is increasingly supportive of a greater incidence of clinically actionable variants in sporadic ALS than previously reported. Salmon et al. outline the need to improve access, and offer genetic testing to all people diagnosed with ALS.

KW - Amyotrophic Lateral Sclerosis/diagnosis

KW - Genetic Testing

KW - Humans

KW - Mutation/genetics

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U2 - 10.1093/brain/awab472

DO - 10.1093/brain/awab472

M3 - Comment/Letter to the editor

C2 - 35020823

SN - 0006-8950

VL - 145

SP - 1207

EP - 1210

JO - Brain : a journal of neurology

JF - Brain : a journal of neurology

IS - 4

ER -

The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis

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