The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants

Pauline Reubsaet; Annemieke J Brouwer; Ingrid C van Haastert; Margaretha J Brouwer; Corine Koopman; Floris Groenendaal; Linda S de Vries

doi:10.1159/000472246

The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants

Pauline Reubsaet, Annemieke J Brouwer, Ingrid C van Haastert, Margaretha J Brouwer, Corine Koopman, Floris Groenendaal, Linda S de Vries

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Very preterm infants often show germinal matrix-intraventricular hemorrhage (GMH-IVH) on cranial ultrasound (cUS).

AIM: To determine the impact of low-grade GMH-IVH on early neurodevelopmental outcome in very preterm infants.

METHODS: A retrospective case-control study in very preterm infants with and without low-grade GMH-IVH on cUS. Additional magnetic resonance imaging (MRI) was available in all infants with a gestational age (GA) <28 weeks and high-risk infants >28 weeks. Infants were seen at 2 years' corrected age to assess neurodevelopment.

RESULTS: In total, 136 infants (GA 24-32 weeks) with low-grade GMH-IVH on cUS were matched with 255 controls. Outcome data was available for 342 (87%) infants. Adverse outcome (i.e., cerebral palsy [CP], neurodevelopmental delay) was present in 11 (9%) cases and 20 (9%) controls. No statistically significant differences in outcome were found between cases and controls. Additional MRI was performed in 165/391 infants (42%) and showed additional lesions in 73 (44%) infants that could explain subsequent development of CP in 2 out of 5 infants and epilepsy in 1 of 2 infants.

CONCLUSION: Very preterm infants with low-grade GMH-IVH on cUS have a similar early neurodevelopmental outcome compared with controls. Additional MRI showed mostly subtle abnormalities that were missed with cUS, but these could not explain subsequent development of CP and developmental delay in all infants.

Original language	English
Pages (from-to)	203-210
Number of pages	8
Journal	Neonatology
Volume	112
Issue number	3
DOIs	https://doi.org/10.1159/000472246
Publication status	Published - Oct 2017

Keywords

Cerebral palsy
Germinal matrix-intraventricular hemorrhage
Hemorrhage
MRI
Outcome
Preterm
Ultrasound

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10.1159/000472246

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@article{843804ddec6644189fa8bbc698b3463b,

title = "The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants",

abstract = "BACKGROUND: Very preterm infants often show germinal matrix-intraventricular hemorrhage (GMH-IVH) on cranial ultrasound (cUS).AIM: To determine the impact of low-grade GMH-IVH on early neurodevelopmental outcome in very preterm infants.METHODS: A retrospective case-control study in very preterm infants with and without low-grade GMH-IVH on cUS. Additional magnetic resonance imaging (MRI) was available in all infants with a gestational age (GA) <28 weeks and high-risk infants >28 weeks. Infants were seen at 2 years' corrected age to assess neurodevelopment.RESULTS: In total, 136 infants (GA 24-32 weeks) with low-grade GMH-IVH on cUS were matched with 255 controls. Outcome data was available for 342 (87%) infants. Adverse outcome (i.e., cerebral palsy [CP], neurodevelopmental delay) was present in 11 (9%) cases and 20 (9%) controls. No statistically significant differences in outcome were found between cases and controls. Additional MRI was performed in 165/391 infants (42%) and showed additional lesions in 73 (44%) infants that could explain subsequent development of CP in 2 out of 5 infants and epilepsy in 1 of 2 infants.CONCLUSION: Very preterm infants with low-grade GMH-IVH on cUS have a similar early neurodevelopmental outcome compared with controls. Additional MRI showed mostly subtle abnormalities that were missed with cUS, but these could not explain subsequent development of CP and developmental delay in all infants.",

keywords = "Cerebral palsy, Germinal matrix-intraventricular hemorrhage, Hemorrhage, MRI, Outcome, Preterm, Ultrasound",

author = "Pauline Reubsaet and Brouwer, {Annemieke J} and {van Haastert}, {Ingrid C} and Brouwer, {Margaretha J} and Corine Koopman and Floris Groenendaal and {de Vries}, {Linda S}",

note = "Publisher Copyright: {\textcopyright} 2017 S. Karger AG, Basel.",

year = "2017",

month = oct,

doi = "10.1159/000472246",

language = "English",

volume = "112",

pages = "203--210",

journal = "Neonatology",

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publisher = "S. Karger AG",

number = "3",

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T1 - The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants

AU - Reubsaet, Pauline

AU - Brouwer, Annemieke J

AU - van Haastert, Ingrid C

AU - Brouwer, Margaretha J

AU - Koopman, Corine

AU - Groenendaal, Floris

AU - de Vries, Linda S

PY - 2017/10

Y1 - 2017/10

N2 - BACKGROUND: Very preterm infants often show germinal matrix-intraventricular hemorrhage (GMH-IVH) on cranial ultrasound (cUS).AIM: To determine the impact of low-grade GMH-IVH on early neurodevelopmental outcome in very preterm infants.METHODS: A retrospective case-control study in very preterm infants with and without low-grade GMH-IVH on cUS. Additional magnetic resonance imaging (MRI) was available in all infants with a gestational age (GA) <28 weeks and high-risk infants >28 weeks. Infants were seen at 2 years' corrected age to assess neurodevelopment.RESULTS: In total, 136 infants (GA 24-32 weeks) with low-grade GMH-IVH on cUS were matched with 255 controls. Outcome data was available for 342 (87%) infants. Adverse outcome (i.e., cerebral palsy [CP], neurodevelopmental delay) was present in 11 (9%) cases and 20 (9%) controls. No statistically significant differences in outcome were found between cases and controls. Additional MRI was performed in 165/391 infants (42%) and showed additional lesions in 73 (44%) infants that could explain subsequent development of CP in 2 out of 5 infants and epilepsy in 1 of 2 infants.CONCLUSION: Very preterm infants with low-grade GMH-IVH on cUS have a similar early neurodevelopmental outcome compared with controls. Additional MRI showed mostly subtle abnormalities that were missed with cUS, but these could not explain subsequent development of CP and developmental delay in all infants.

AB - BACKGROUND: Very preterm infants often show germinal matrix-intraventricular hemorrhage (GMH-IVH) on cranial ultrasound (cUS).AIM: To determine the impact of low-grade GMH-IVH on early neurodevelopmental outcome in very preterm infants.METHODS: A retrospective case-control study in very preterm infants with and without low-grade GMH-IVH on cUS. Additional magnetic resonance imaging (MRI) was available in all infants with a gestational age (GA) <28 weeks and high-risk infants >28 weeks. Infants were seen at 2 years' corrected age to assess neurodevelopment.RESULTS: In total, 136 infants (GA 24-32 weeks) with low-grade GMH-IVH on cUS were matched with 255 controls. Outcome data was available for 342 (87%) infants. Adverse outcome (i.e., cerebral palsy [CP], neurodevelopmental delay) was present in 11 (9%) cases and 20 (9%) controls. No statistically significant differences in outcome were found between cases and controls. Additional MRI was performed in 165/391 infants (42%) and showed additional lesions in 73 (44%) infants that could explain subsequent development of CP in 2 out of 5 infants and epilepsy in 1 of 2 infants.CONCLUSION: Very preterm infants with low-grade GMH-IVH on cUS have a similar early neurodevelopmental outcome compared with controls. Additional MRI showed mostly subtle abnormalities that were missed with cUS, but these could not explain subsequent development of CP and developmental delay in all infants.

KW - Cerebral palsy

KW - Germinal matrix-intraventricular hemorrhage

KW - Hemorrhage

KW - MRI

KW - Outcome

KW - Preterm

KW - Ultrasound

U2 - 10.1159/000472246

DO - 10.1159/000472246

M3 - Article

C2 - 28704824

SN - 1661-7800

VL - 112

SP - 203

EP - 210

JO - Neonatology

JF - Neonatology

IS - 3

ER -

The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants

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Keywords

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