The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination

Esther J M Taks; Simone J C F M Moorlag; Konstantin Föhse; Elles Simonetti; Christa E van der Gaast-de Jongh; Cornelis H van Werkhoven; Marc J M Bonten; Jaap Ten Oever; Marien I de Jonge; Janneke H H M van de Wijgert; Mihai G Netea

doi:10.1016/j.isci.2023.108062

The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination

Esther J M Taks^*, Simone J C F M Moorlag, Konstantin Föhse, Elles Simonetti, Christa E van der Gaast-de Jongh, Cornelis H van Werkhoven, Marc J M Bonten, Jaap Ten Oever, Marien I de Jonge, Janneke H H M van de Wijgert, Mihai G Netea

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329-359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population.

Original language	English
Article number	108062
Number of pages	12
Journal	iScience
Volume	26
Issue number	11
DOIs	https://doi.org/10.1016/j.isci.2023.108062
Publication status	Published - 17 Nov 2023

Keywords

health sciences
medical science
microbiology
virology

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1-s2.0-S2589004223021399-mainFinal published version, 2.82 MBLicence: CC BY

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Taks, E. J. M., Moorlag, S. J. C. F. M., Föhse, K., Simonetti, E., van der Gaast-de Jongh, C. E., van Werkhoven, C. H., Bonten, M. J. M., Oever, J. T., de Jonge, M. I., van de Wijgert, J. H. H. M., & Netea, M. G. (2023). The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination. iScience, 26(11), Article 108062. https://doi.org/10.1016/j.isci.2023.108062

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title = "The impact of Bacillus Calmette-Gu{\'e}rin vaccination on antibody response after COVID-19 vaccination",

abstract = "Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329-359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population.",

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AU - van der Gaast-de Jongh, Christa E

AU - van Werkhoven, Cornelis H

AU - Bonten, Marc J M

AU - Oever, Jaap Ten

AU - de Jonge, Marien I

AU - van de Wijgert, Janneke H H M

AU - Netea, Mihai G

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The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination

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